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Irradiation effects on antibody performance in the frame of biochip-based instruments development for space exploration

hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorBAQUÉ, M.
hal.structure.identifierASP 2017
dc.contributor.authorDOBRIJEVIC, M.
hal.structure.identifierASP 2017
dc.contributor.authorLE POSTOLLEC, A.
hal.structure.identifierGénétique, Reproduction et Développement [GReD]
dc.contributor.authorMOREAU, Thibault
hal.structure.identifierCOLCOM
dc.contributor.authorFAYE, C.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorVIGIER, F.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorCOUSSOT, G.
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorCARON, J.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorVANDENABEELE-TRAMBOUZE, O.
dc.date.issued2017
dc.identifier.issn1473-5504
dc.description.abstractEnSeveral instruments based on immunoassay techniques have been proposed for life-detection experiments in the framework of planetary exploration but few experiments have been conducted so far to test the resistance of antibodies against cosmic ray particles. We present several irradiation experiments carried out on both grafted and free antibodies for different types of incident particles (protons, neutrons, electrons and 12C) at different energies (between 9 MeV and 50 MeV) and different fluences. No loss of antibodies activity was detected for the whole set of experiments except when considering protons with energy between 20 and 30 MeV (on free and grafted antibodies) and fluences much greater than expected for a typical planetary mission to Mars for instance. Our results on grafted antibodies suggest that biochip-based instruments must be carefully designed according to the expected radiation environment for a given mission. In particular, a surface density of antibodies much larger than the expected proton fluence would prevent significant loss of antibodies activity and thus assuring a successful detection.
dc.language.isoen
dc.publisherCambridge University Press (CUP)
dc.subject.ensearch for extraterrestrial life
dc.subject.encosmic rays
dc.subject.enbiochip
dc.subject.enastrobiology
dc.title.enIrradiation effects on antibody performance in the frame of biochip-based instruments development for space exploration
dc.typeArticle de revue
dc.identifier.doi10.1017/S1473550415000555
dc.subject.halPlanète et Univers [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
bordeaux.journalInternational Journal of Astrobiology
bordeaux.page82-90
bordeaux.volume16
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-01285933
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01285933v1
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