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Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects

dc.rights.licenseopenen_US
dc.contributor.authorLATXAGUE, Laurent
dc.contributor.authorBENIZRI, Sebastien
dc.contributor.authorGAUBERT, Alexandra
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorTOLCHARD, James
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMARTINEZ, Denis
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorMORVAN, Estelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGRELARD, Axelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSAAD, Ahmad
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHABENSTEIN, Birgit
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLOQUET, Antoine
dc.contributor.authorBARTHELEMY, Philippe
dc.date.accessioned2021-06-30T15:30:05Z
dc.date.available2021-06-30T15:30:05Z
dc.date.issued2021
dc.identifier.issn0021-9797en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/94949
dc.description.abstractEnSupramolecular chemistry has garnered important interest in recent years toward improving therapeutic efficacy via drug delivery approaches. Although self-assemblies have been deeply investigated, the design of novel drugs leveraging supramolecular chemistry is less known. In this contribution, we show that a Low Molecular Weight Gel (LMWG) can elicit cancer cell apoptosis. This biological effect results from the unique supramolecular properties of a bolaamphiphile-based gelator, which allow for strong interaction with the lipid membrane. This novel supramolecular-drug paradigm opens up new possibilities for therapeutic applications targeting membrane lipids. (c) 2021 Elsevier Inc. All rights reserved.
dc.language.isoENen_US
dc.subject.enSupramolecular
dc.subject.enBolaamphiphiles
dc.subject.enHydrogels
dc.subject.enMembrane
dc.subject.enFluorocarbon
dc.title.enBolaamphiphile-based supramolecular gels with drugs eliciting membrane effects
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jcis.2021.03.026en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalJournal of Colloid and Interface Scienceen_US
bordeaux.page857-863en_US
bordeaux.volume594en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03218941
hal.exportfalse
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