Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects
| dc.rights.license | open | en_US |
| dc.contributor.author | LATXAGUE, Laurent
ORCID: 0000-0002-6115-7437 IDREF: 074748114 | |
| dc.contributor.author | BENIZRI, Sebastien | |
| dc.contributor.author | GAUBERT, Alexandra
IDREF: 150487983 | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | TOLCHARD, James | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | MARTINEZ, Denis | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| dc.contributor.author | MORVAN, Estelle | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GRELARD, Axelle | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | SAAD, Ahmad | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | HABENSTEIN, Birgit | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LOQUET, Antoine | |
| dc.contributor.author | BARTHELEMY, Philippe | |
| dc.date.accessioned | 2021-06-30T15:30:05Z | |
| dc.date.available | 2021-06-30T15:30:05Z | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 0021-9797 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/94949 | |
| dc.description.abstractEn | Supramolecular chemistry has garnered important interest in recent years toward improving therapeutic efficacy via drug delivery approaches. Although self-assemblies have been deeply investigated, the design of novel drugs leveraging supramolecular chemistry is less known. In this contribution, we show that a Low Molecular Weight Gel (LMWG) can elicit cancer cell apoptosis. This biological effect results from the unique supramolecular properties of a bolaamphiphile-based gelator, which allow for strong interaction with the lipid membrane. This novel supramolecular-drug paradigm opens up new possibilities for therapeutic applications targeting membrane lipids. (c) 2021 Elsevier Inc. All rights reserved. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Supramolecular | |
| dc.subject.en | Bolaamphiphiles | |
| dc.subject.en | Hydrogels | |
| dc.subject.en | Membrane | |
| dc.subject.en | Fluorocarbon | |
| dc.title.en | Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jcis.2021.03.026 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Journal of Colloid and Interface Science | en_US |
| bordeaux.page | 857-863 | en_US |
| bordeaux.volume | 594 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03218941 | |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Colloid%20and%20Interface%20Science&rft.date=2021&rft.volume=594&rft.spage=857-863&rft.epage=857-863&rft.eissn=0021-9797&rft.issn=0021-9797&rft.au=LATXAGUE,%20Laurent&BENIZRI,%20Sebastien&GAUBERT,%20Alexandra&TOLCHARD,%20James&MARTINEZ,%20Denis&rft.genre=article |
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