LATXAGUE, Laurent; BENIZRI, Sebastien; GAUBERT, Alexandra; TOLCHARD, James; MARTINEZ, Denis; MORVAN, Estelle; GRELARD, Axelle; SAAD, Ahmad; HABENSTEIN, Birgit; LOQUET, Antoine; BARTHELEMY, Philippe

doi:10.1016/j.jcis.2021.03.026

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Journal of Colloid and Interface Science. 2021, vol. 594, p. 857-863

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Supramolecular chemistry has garnered important interest in recent years toward improving therapeutic efficacy via drug delivery approaches. Although self-assemblies have been deeply investigated, the design of novel drugs leveraging supramolecular chemistry is less known. In this contribution, we show that a Low Molecular Weight Gel (LMWG) can elicit cancer cell apoptosis. This biological effect results from the unique supramolecular properties of a bolaamphiphile-based gelator, which allow for strong interaction with the lipid membrane. This novel supramolecular-drug paradigm opens up new possibilities for therapeutic applications targeting membrane lipids. (c) 2021 Elsevier Inc. All rights reserved.< Leer menos

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Supramolecular

Bolaamphiphiles

Hydrogels

Membrane

Fluorocarbon

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Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects

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