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Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration

dc.rights.licenseopenen_US
dc.contributor.authorJOHNSON, L. F.
dc.contributor.authorANDEREGG, N.
dc.contributor.authorZANIEWSKI, E.
dc.contributor.authorEATON, J. W.
dc.contributor.authorREBEIRO, P. F.
dc.contributor.authorCARRIQUIRY, G.
dc.contributor.authorNASH, D.
dc.contributor.authorYOTEBIENG, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorEKOUEVI, Didier K
dc.contributor.authorHOLMES, C. B.
dc.contributor.authorCHOI, J. Y.
dc.contributor.authorJIAMSAKUL, A.
dc.contributor.authorBAKOYANNIS, G.
dc.contributor.authorALTHOFF, K. N.
dc.contributor.authorSOHN, A. H.
dc.contributor.authorYIANNOUTSOS, C.
dc.contributor.authorEGGER, M.
dc.contributor.authorINTERNATIONAL EPIDEMIOLOGY DATABASES TO EVALUATE, Aids Collaboration
dc.date.accessioned2020-06-25T09:25:02Z
dc.date.available2020-06-25T09:25:02Z
dc.date.issued2019-12-15
dc.identifier.issn0269-9370en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8191
dc.description.abstractEnBACKGROUND: UNAIDS models use data from the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration in setting assumptions about mortality rates after antiretroviral treatment (ART) initiation. This study aims to update these assumptions with new data, to quantify the extent of regional variation in ART mortality and to assess trends in ART mortality. METHODS: Adult ART patients from Africa, Asia and the Americas were included if they had a known date of ART initiation during 2001-2017 and a baseline CD4 cell count. In cohorts that relied only on passive follow-up (no patient tracing or linkage to vital registration systems), mortality outcomes were imputed in patients lost to follow-up based on a meta-analysis of tracing study data. Poisson regression models were fitted to the mortality data. RESULTS: 464 048 ART patients were included. In multivariable analysis, mortality rates were lowest in Asia and highest in Africa, with no significant differences between African regions. Adjusted mortality rates varied significantly between programmes within regions. Mortality rates in the first 12 months after ART initiation were significantly higher during 2001-2006 than during 2010-2014, although the difference was more substantial in Asia and the Americas [adjusted incidence rate ratio (aIRR) 1.43, 95% CI: 1.22-1.66] than in Africa (aIRR 1.07, 95% CI: 1.04-1.11). CONCLUSION: There is substantial variation in ART mortality between and within regions, even after controlling for differences in mortality by age, sex, baseline CD4 category and calendar period. ART mortality rates have declined substantially over time, although declines have been slower in Africa.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.enIDLIC
dc.subject.enIeDEA
dc.title.enGlobal variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000002358en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31800405en_US
bordeaux.journalAIDSen_US
bordeaux.pageS283-s294en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209843
hal.version1
hal.date.transferred2021-04-27T12:53:29Z
hal.exporttrue
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