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Development of an injectable composite for bone regeneration

hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorJACQUART, Sylvaine
hal.structure.identifierCentre de Recherches sur les Macromolécules Végétales [CERMAV]
dc.contributor.authorBELIME, Agathe
dc.contributor.authorHÉNOCQ-PIGASSE, Christel
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorFATNASSI, Mohammed
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorTADIER, Solene
hal.structure.identifierCentre de Recherches sur les Macromolécules Végétales [CERMAV]
dc.contributor.authorAUZÉLY-VELTY, Rachel
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorGIROD-FULLANA, Sophie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
dc.contributor.authorROQUES, Christine
hal.structure.identifierLaboratoire de rhéologie [LR]
dc.contributor.authorEL KISSI, Nadia
hal.structure.identifierBioingénierie et Bioimagerie Ostéo-articulaires ; Biomécanique et Biomatériaux Ostéo-Articulaires [B2OA (UMR_7052)]
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorANAGNOSTOU, Fani
hal.structure.identifierMedicalGroup (FRANCE)
dc.contributor.authorBIGNON, Aurélien
hal.structure.identifierMedicalGroup (FRANCE)
dc.contributor.authorCORDIER, Delphine
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorREY, Christian
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorBROUILLET, Fabien
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMÉDÉE, Joelle
hal.structure.identifierLaboratoire de rhéologie [LR]
dc.contributor.authorGALLIARD, Hélène
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorCOMBES, Christèle
dc.date.accessioned2021-06-10T07:05:58Z
dc.date.available2021-06-10T07:05:58Z
dc.date.issued2013-04
dc.identifier.issn1959-0318
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79056
dc.description.abstractEnWith the development of minimally invasive surgical techniques, there is a growing interest in the research and development of injectable biomaterials especially for orthopedic applications. In a view to enhance the overall surgery benefits for the patient, the BIOSINJECT project aims at preparing a new generation of mineral-organic composites for bone regeneration exhibiting bioactivity, therapeutic activity and easiness of use to broaden the application domains of the actual bone mineral cements and propose an alternative strategy with regard to their poor resorbability, injectability difficulties and risk of infection. First, a physical-chemical study demonstrated the feasibility of self-setting injectable composites associating calcium carbonate-calcium phosphate cement and polysaccharides (tailor-made or commercial polymer) in the presence or not of an antibacterial agent within the composite formulation. Then, bone cell response and antimicrobial activity of the composite have been evaluated in vitro. Finally, in order to evaluate resorption rate and bone tissue response an animal study has been performed and the histological analysis is still in progress. These multidisciplinary and complementary studies led to promising results in a view of the industrial development of such composite for dental and orthopaedic applications.
dc.language.isoen
dc.publisherElsevier Masson
dc.title.enDevelopment of an injectable composite for bone regeneration
dc.typeArticle de revue
dc.identifier.doi10.1016/j.irbm.2013.01.008
dc.subject.halSciences de l'ingénieur [physics]/Matériaux
dc.subject.halSciences de l'ingénieur [physics]/Micro et nanotechnologies/Microélectronique
bordeaux.journalInnovation and Research in BioMedical engineering
bordeaux.pagepp. 176-179
bordeaux.volumevol. 34
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-00869869
hal.version1
dc.subject.itCalcium carbonate-calcium phosphate
dc.subject.itCement
dc.subject.itComposite
dc.subject.itBone regeneration
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00869869v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Innovation%20and%20Research%20in%20BioMedical%20engineering&rft.date=2013-04&rft.volume=vol.%2034&rft.spage=pp.%20176-179&rft.epage=pp.%20176-179&rft.eissn=1959-0318&rft.issn=1959-0318&rft.au=JACQUART,%20Sylvaine&BELIME,%20Agathe&H%C3%89NOCQ-PIGASSE,%20Christel&SIADOUS,%20Robin&FATNASSI,%20Mohammed&rft.genre=article


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