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Composition and properties of silver-containing calcium carbonate–calcium phosphate bone cement

hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorJACQUART, Sylvaine
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
dc.contributor.authorHÉNOCQ-PIGASSE, Christel
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
dc.contributor.authorROQUES, Christine
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorREY, Christian
hal.structure.identifierCentre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
dc.contributor.authorCOMBES, Christèle
dc.date.accessioned2021-06-10T07:05:56Z
dc.date.available2021-06-10T07:05:56Z
dc.date.issued2013-12
dc.identifier.issn0957-4530
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79053
dc.description.abstractEnThe introduction of silver, either in the liquid phase (as silver nitrate solution: Ag(L)) or in the solid phase (as silver phosphate salt: Ag(S)) of calcium carbonate–calcium phosphate (CaCO3–CaP) bone cement, its influence on the composition of the set cement (C-Ag(L)and C-Ag(S) cements with a Ca/Ag atomic ratio equal to 10.3) and its biological properties were investigated. The fine characterisation of the chemical setting of silver-doped and reference cements was performed using FTIR spectroscopy. We showed that the formation of apatite was enhanced from the first hours of maturation of C-Ag(L) cement in comparison with the reference cement, whereas a longer period of maturation (about 10 h) was required to observe this increase for C-Ag(S) cement, although in both cases, silver was present in the set cements mainly as silver phosphate. The role of silver nitrate on the setting chemical reaction is discussed and a chemical scheme is proposed. Antibacterial activity tests (S. aureus and S. epidermidis) and in vitro cytotoxicity tests (human bone marrow stromal cells (HBMSC)) showed that silver-loaded CaCO3–CaP cements had antibacterial properties (anti-adhesion and anti-biofilm formation) without a toxic effect on HBMSC cells, making C-Ag(S) cement a promising candidate for the prevention of bone implant-associated infections.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enBone cement
dc.subject.enSilver
dc.subject.enPhysico-chemistry
dc.subject.enAntibacterial activity
dc.subject.enCytotoxicity
dc.title.enComposition and properties of silver-containing calcium carbonate–calcium phosphate bone cement
dc.typeArticle de revue
dc.identifier.doi10.1007/s10856-013-5014-2
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.subject.halSciences de l'ingénieur [physics]/Matériaux
bordeaux.journalJournal of Materials Science: Materials in Medicine
bordeaux.pagepp. 2665-2675
bordeaux.volumeVol. 24
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issuen° 12
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-01153078
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01153078v1
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