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Risk profile, quality of life and care of patients with moderate and advanced CKD : The French CKD-REIN Cohort Study

hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, Benedicte
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorMETZGER, Marie
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
dc.contributor.authorJACQUELINET, Denis
hal.structure.identifierCentre d'investigation clinique [Nancy] [CIC]
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
dc.contributor.authorBRIANÇON, Serge
hal.structure.identifierRéseau Lorrain de prise en charge de l’insuffisance rénale chronique : Réseau NEPHROLOR [Nephrolor]
hal.structure.identifierCentre d'investigation clinique [Nancy] [CIC]
dc.contributor.authorAYAV, Carole
hal.structure.identifierService de néphrologie
dc.contributor.authorFOUQUE, Denis
hal.structure.identifierService de néphrologie
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
hal.structure.identifierService de Néphrologie [CHRU Nancy]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierUniversité Jean Moulin - Lyon 3 [UJML]
dc.contributor.authorPASCAL, Christophe
hal.structure.identifierBiobanque de Picardie [CHU Amiens - Hôpital Sud]
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorHERPE, Yves-Edouard
hal.structure.identifierEtablissement français du sang [Bourgogne-Franche-Comté] [EFS BFC]
dc.contributor.authorMOREL, Pascal
hal.structure.identifierCentre National de Recherche en Génomique Humaine [CNRGH]
dc.contributor.authorDELEUZE, Jean-François
hal.structure.identifierEquipe 7 Inserm U1048
hal.structure.identifierUniversité Toulouse III - Paul Sabatier [UT3]
dc.contributor.authorSCHANSTRA, Joost
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
dc.contributor.authorLANGE, Céline
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
hal.structure.identifierCentre d'investigation clinique [Nancy] [CIC]
dc.contributor.authorLEGRAND, Karine
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSPEYER, Elodie
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorLIABEUF, Sophie
hal.structure.identifierArbor Research Collaborative for Health
dc.contributor.authorROBINSON, Bruce
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierService Néphrologie/Dialyse [AP-HP Ambroise-Paré]
dc.contributor.authorMASSY, Ziad
dc.date.accessioned2021-06-10T07:05:31Z
dc.date.available2021-06-10T07:05:31Z
dc.date.issued2018-04-09
dc.identifier.issn0931-0509
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79024
dc.description.abstractEnBackground: The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study was designed to investigate the determinants of prognosis and care of patients referred to nephrologists with moderate and advanced chronic kidney disease (CKD). We examined their baseline risk profile and experience.Methods: We collected bioclinical and patient-reported information from 3033 outpatients with CKD and estimated glomerular filtration rates (eGFRs) of 15-60 mL/min/1.73 m2 treated at 40 nationally representative public and private facilities.Results: The patients' median age was 69 (60-76) years, 65% were men, their mean eGFR was 33 mL/min/1.73 m2, 43% had diabetes, 24% had a history of acute kidney injury (AKI) and 57% had uncontrolled blood pressure (BP; >140/90 mmHg). Men had worse risk profiles than women and were more likely to be past or current smokers (73% versus 34%) and have cardiovascular disease (59% versus 42%), albuminuria >30 mg/mmol (or proteinuria > 50) (40% versus 30%) (all P < 0.001) and a higher median risk of end-stage renal disease within 5 years, predicted by the kidney failure risk equation {12% [interquartile range (IQR) 3-37%] versus 9% [3-31%], P = 0.008}. During the previous year, 60% of patients reported one-to-two nephrologist visits and four or more general practitioner visits; only 25% saw a dietician and 75% were prescribed five or more medications daily. Physical and mental quality of life (QoL) were poor, with scores <50/100.Conclusions: The CKD-REIN study highlights high-risk profiles of cohort members and identifies several priorities, including improving BP control and dietary counselling and increasing doctors' awareness of AKI, polypharmacy and QoL.
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.title.enRisk profile, quality of life and care of patients with moderate and advanced CKD : The French CKD-REIN Cohort Study
dc.typeArticle de revue
dc.identifier.doi10.1093/ndt/gfy058
dc.subject.halSciences de l'Homme et Société/Gestion et management
bordeaux.journalNephrology Dialysis Transplantation
bordeaux.page277-286
bordeaux.volume34
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue2
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-01807654
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01807654v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Nephrology%20Dialysis%20Transplantation&amp;rft.date=2018-04-09&amp;rft.volume=34&amp;rft.issue=2&amp;rft.spage=277-286&amp;rft.epage=277-286&amp;rft.eissn=0931-0509&amp;rft.issn=0931-0509&amp;rft.au=STENGEL,%20Benedicte&amp;METZGER,%20Marie&amp;COMBE,%20Christian&amp;JACQUELINET,%20Denis&amp;BRIAN%C3%87ON,%20Serge&amp;rft.genre=article


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