| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| hal.structure.identifier | Service Néphrologie/Dialyse [AP-HP Ambroise-Paré] | |
| dc.contributor.author | VILLAIN, Cédric | |
| hal.structure.identifier | CHU Amiens-Picardie | |
| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| dc.contributor.author | LIABEUF, Sophie | |
| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| dc.contributor.author | METZGER, Marie | |
| hal.structure.identifier | Service de Néphrologie-transplantation-dialyse [Bordeaux] | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | COMBE, Christian | |
| hal.structure.identifier | Service de néphrologie | |
| hal.structure.identifier | Cardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN] | |
| dc.contributor.author | FOUQUE, Denis | |
| hal.structure.identifier | Service de Néphrologie [CHRU Nancy] | |
| hal.structure.identifier | Maladies chroniques, santé perçue, et processus d'adaptation [APEMAC] | |
| dc.contributor.author | FRIMAT, Luc | |
| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| hal.structure.identifier | Agence de la biomédecine [Saint-Denis la Plaine] | |
| dc.contributor.author | JACQUELINET, Christian | |
| hal.structure.identifier | Service de Néphrologie [Lyon] | |
| hal.structure.identifier | Cardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN] | |
| dc.contributor.author | LAVILLE, Maurice | |
| hal.structure.identifier | Maladies chroniques, santé perçue, et processus d'adaptation [APEMAC] | |
| hal.structure.identifier | Centre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC] | |
| dc.contributor.author | BRIANÇON, Serge | |
| hal.structure.identifier | Arbor Research Collaborative for Health | |
| dc.contributor.author | PISONI, Ronald | |
| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| hal.structure.identifier | Service de cardiologie et maladies vasculaires [CHU Ambroise Paré] | |
| dc.contributor.author | MANSENCAL, Nicolas | |
| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| dc.contributor.author | STENGEL, Bénédicte | |
| hal.structure.identifier | Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) [U1018 (Équipe 5)] | |
| hal.structure.identifier | Service Néphrologie/Dialyse [AP-HP Ambroise-Paré] | |
| dc.contributor.author | MASSY, Ziad | |
| dc.date.accessioned | 2021-06-10T07:04:31Z | |
| dc.date.available | 2021-06-10T07:04:31Z | |
| dc.date.issued | 2020-04-01 | |
| dc.identifier.issn | 2048-8505 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78980 | |
| dc.description.abstractEn | Background: Elderly patients with chronic kidney disease (CKD) are often excluded from clinical trials; this may affect their use of essential drugs for cardiovascular complications. We sought to assess the impact of age on cardiovascular drug use in elderly patients with CKD.Methods: We used baseline data from the Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort including 3033 adult patients with CKD Stages 3 and 4. We studied the use of recommended drugs for coronary artery disease (CAD), stroke and atrial fibrillation by age, after adjusting for socio-demographic and clinical conditions.Results: The patients' mean age was 66.8 years (mean estimated glomerular filtration rate 32.9 mL/min/1.73 m2). The prevalence of CAD was 24.5% [81.3% receiving antiplatelet agents, 75.6% renin-angiotensin system (RAS) blockers, 65.4% β-blockers and 81.3% lipid-lowering therapy], that of stroke 10.0% (88.8% receiving antithrombotic drugs) and that of atrial fibrillation 11.1% (69.5% receiving oral anticoagulants). Compared with patients aged <65 years, older age (≥65 years) was associated with greater use of antithrombotic drugs in stroke [adjusted odds ratio (aOR) (95% confidence interval) = 2.83 (1.04-7.73) for patients aged (75-84 years)] and less use of RAS blockers [aOR = 0.39 (0.16-0.89) for patients aged ≥85 years], β-blockers [aOR = 0.31 (0.19-0.53) for patients aged 75-84 years] and lipid-lowering therapy [aOR = 0.39 (0.15-1.02) for patients aged ≥85 years, P for trend = 0.01] in CAD. Older age was not associated with less use of antiplatelet agents in CAD or oral anticoagulants in atrial fibrillation.Conclusions: In patients with CKD, older age per se was not associated with the underuse of antithrombotic drugs but was for other major drugs, with a potential impact on cardiovascular outcomes. | |
| dc.language.iso | en | |
| dc.publisher | Oxford University Press | |
| dc.subject.en | atrial fibrillation | |
| dc.subject.en | chronic kidney disease | |
| dc.subject.en | coronary artery disease | |
| dc.subject.en | elderly | |
| dc.subject.en | stroke | |
| dc.subject.en | underuse | |
| dc.title.en | Impact of age on cardiovascular drug use in patients with chronic kidney disease | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1093/ckj/sfz063 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | |
| bordeaux.journal | Clinical Kidney Journal | |
| bordeaux.page | 199-207 | |
| bordeaux.volume | 13 | |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | * |
| bordeaux.issue | 2 | |
| bordeaux.institution | CNRS | |
| bordeaux.institution | INSERM | |
| bordeaux.institution | CHU de Bordeaux | |
| bordeaux.institution | Institut Bergonié | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02572053 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02572053v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Kidney%20Journal&rft.date=2020-04-01&rft.volume=13&rft.issue=2&rft.spage=199-207&rft.epage=199-207&rft.eissn=2048-8505&rft.issn=2048-8505&rft.au=VILLAIN,%20C%C3%A9dric&LIABEUF,%20Sophie&METZGER,%20Marie&COMBE,%20Christian&FOUQUE,%20Denis&rft.genre=article | |
