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A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

hal.structure.identifierThe Barcelona Institute for Science and Technology [Barcelona, Spain]
dc.contributor.authorVILLENEUVE, Julien
hal.structure.identifierMaintenance Myélinique et Neuropathies Périphériques [MMNP]
dc.contributor.authorDESMOULIÈRE, Alexis
hal.structure.identifierService d'anesthésie-réanimation [CHU Bordeaux]
dc.contributor.authorDEWITTE, Antoine
hal.structure.identifierMaintenance Myélinique et Neuropathies Périphériques [MMNP]
dc.contributor.authorBORDEAU, Nelly
hal.structure.identifierService Commun des Animaleries [Bordeaux]
dc.contributor.authorCOSTET, Pierre
hal.structure.identifierUniversity of California [San Francisco] [UC San Francisco]
dc.contributor.authorBASSAGANYAS, Laia
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, Jean-Christophe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorRIPOCHE, Jean
hal.structure.identifierService de pathologie [Bordeaux]
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorLEPREUX, Sébastien
dc.date.accessioned2021-06-10T07:04:04Z
dc.date.available2021-06-10T07:04:04Z
dc.date.issued2017
dc.identifier.issn0962-9351
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78950
dc.description.abstractEnGranulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.title.enA Role for CD154, the CD40 Ligand, in Granulomatous Inflammation
dc.typeArticle de revue
dc.identifier.doi10.1155/2017/2982879
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalMediators of Inflammation
bordeaux.page2982879
bordeaux.volume2017
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870606
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870606v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Mediators%20of%20Inflammation&rft.date=2017&rft.volume=2017&rft.spage=2982879&rft.epage=2982879&rft.eissn=0962-9351&rft.issn=0962-9351&rft.au=VILLENEUVE,%20Julien&DESMOULI%C3%88RE,%20Alexis&DEWITTE,%20Antoine&BORDEAU,%20Nelly&COSTET,%20Pierre&rft.genre=article


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