VILLENEUVE, Julien; DESMOULIÈRE, Alexis; DEWITTE, Antoine; BORDEAU, Nelly; COSTET, Pierre; BASSAGANYAS, Laia; FRICAIN, Jean-Christophe; RIPOCHE, Jean; LEPREUX, Sébastien

doi:10.1155/2017/2982879

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VILLENEUVE, Julien
The Barcelona Institute for Science and Technology [Barcelona, Spain]

DESMOULIÈRE, Alexis
Maintenance Myélinique et Neuropathies Périphériques [MMNP]

DEWITTE, Antoine

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Mediators of Inflammation. 2017, vol. 2017, p. 2982879

Hindawi Publishing Corporation

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Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.< Réduire

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A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

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