Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | SEENEEVASSEN, Lornella | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | GIRAUD, Julie | |
hal.structure.identifier | Universidad de Costa Rica [UCR] | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | MOLINA-CASTRO, Silvia | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | SIFRÉ, Elodie | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | TIFFON, Camille | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | BEAUVOIT, Clémentine | |
hal.structure.identifier | Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA] | |
dc.contributor.author | STAEDEL, Cathy | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | MÉGRAUD, Francis | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | LEHOURS, Philippe | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | MARTIN, Océane | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | BOEUF, Hélène
ORCID: 0000-0002-3006-8773 IDREF: 03205453X | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | DUBUS, Pierre | |
hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
dc.contributor.author | VARON, Christine | |
dc.date.accessioned | 2021-06-10T07:03:27Z | |
dc.date.available | 2021-06-10T07:03:27Z | |
dc.date.issued | 2020-08 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78916 | |
dc.description.abstractEn | Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour maintenance and recurrence, making their targeting of utmost importance in gastric cancer (GC) therapy. The Hippo pathway has been implicated in gastric CSC properties and was shown to be regulated by leukaemia inhibitory factor receptor (LIFR) and its ligand LIF in breast cancer. This study aimed to determine LIF's effect on CSC properties in GC cell lines and patient-derived xenograft (PDX) cells, which remains unexplored. LIF's treatment effect on CSC markers expression and tumoursphere formation was evaluated. The Hippo kinase inhibitor XMU-MP-1 and/or the JAK1 inhibitor Ruxolitinib were used to determine Hippo and canonical JAK/STAT pathway involvement in gastric CSCs' response to LIF. Results indicate that LIF decreased tumorigenic and chemo-resistant CSCs, in both GC cell lines and PDX cells. In addition, LIF increased activation of LATS1/2 Hippo kinases, thereby decreasing downstream YAP/TAZ nuclear accumulation and TEAD transcriptional activity. LIF's anti-CSC effect was reversed by XMU-MP-1 but not by Ruxolitinib treatment, highlighting the opposite effects of these two pathways downstream LIFR. In conclusion, LIF displays anti-CSC properties in GC, through Hippo kinases activation, and could in fine constitute a new CSCs-targeting strategy to help decrease relapse cases and bad prognosis in GC. | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.subject.en | JAK | |
dc.subject.en | ALDH | |
dc.subject.en | CD44 | |
dc.subject.en | YAP | |
dc.subject.en | LATS1/2 | |
dc.subject.en | GP190 | |
dc.subject.en | gastric carcinoma | |
dc.subject.en | Ruxolitinib | |
dc.subject.en | XMU-MP-1 | |
dc.title.en | Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer | |
dc.type | Article de revue | |
dc.identifier.doi | 10.3390/cancers12082011 | |
dc.subject.hal | Sciences du Vivant [q-bio] | |
bordeaux.journal | Cancers | |
bordeaux.page | 2011 | |
bordeaux.volume | 12 | |
bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | * |
bordeaux.issue | 8 | |
bordeaux.institution | CNRS | |
bordeaux.institution | INSERM | |
bordeaux.institution | CHU de Bordeaux | |
bordeaux.institution | Institut Bergonié | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-03038893 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-03038893v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2020-08&rft.volume=12&rft.issue=8&rft.spage=2011&rft.epage=2011&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=SEENEEVASSEN,%20Lornella&GIRAUD,%20Julie&MOLINA-CASTRO,%20Silvia&SIFR%C3%89,%20Elodie&TIFFON,%20Camille&rft.genre=article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |