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Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients.

hal.structure.identifierThéoriser et modéliser pour aménager (UMR 6049) [ThéMA]
dc.contributor.authorPIARROUX, Martine
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
hal.structure.identifierUniversité de la Méditerranée - Aix-Marseille 2
dc.contributor.authorPIARROUX, Renaud
hal.structure.identifierLaboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale [LERTIM]
dc.contributor.authorGIORGI, Roch
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
hal.structure.identifierWHO Collaborating Center on Prevention and Treatment of Human Echinococcosis
dc.contributor.authorKNAPP, Jenny
dc.contributor.authorBARDONNET, Karine
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
dc.contributor.authorSUDRE, Bertrand
dc.contributor.authorWATELET, Jérôme
dc.contributor.authorDUMORTIER, Jérôme
dc.contributor.authorGÉRARD, Alain
dc.contributor.authorBEYTOUT, Jean
dc.contributor.authorABERGEL, Armand
hal.structure.identifierWHO Collaborating Center on Prevention and Treatment of Human Echinococcosis
dc.contributor.authorMANTION, Georges
hal.structure.identifierWHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, SERF Unit
hal.structure.identifierCarcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) [CEF2P / CARCINO]
dc.contributor.authorVUITTON, Dominique A
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
hal.structure.identifierWHO Collaborating Center on Prevention and Treatment of Human Echinococcosis
dc.contributor.authorBRESSON-HADNI, Solange
dc.date.accessioned2021-05-14T10:04:30Z
dc.date.available2021-05-14T10:04:30Z
dc.date.issued2011-11
dc.identifier.issn0168-8278
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78490
dc.description.abstractEnBACKGROUND & AIMS: Alveolar echinococcosis (AE) is a rare disease in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis. METHODS: We present here 387 detailed AE cases diagnosed in France from 1982 to 2007 actively identified by a retrospective survey performed in 1997-1998 and prospectively thereafter. RESULTS: Male:female ratio was 1.03 and mean age 57.8 years at time of diagnosis. Among the 362 complete files (including 347 non dead-out and 15 dead-out lesions), 73% of the patients were symptomatic at first admittance. Among them, 83% presented with clinical patterns evocative either of a digestive or a hepatic disorder. Other symptomatic patients presented with erratic clinical pictures, generally due to metastasis or extra-hepatic location of the parasite. Except for a few patients with particularly severe AE who died shortly after the diagnosis, most patients were treated using benzimidazoles. Their mortality tends to merge with that of the general French population, matched by sex, age, and calendar year. This study also highlights an unexpectedly high frequency of blood-tied family cases (13% of patients submitted to a specific questionnaire). CONCLUSIONS: Even though the broad set of clinical features provoked by E. multilocularis makes AE a potential diagnostic trap for many physicians, our study revealed an improvement of its prognosis. However, as shown by our findings about the frequency of family cases, there is still a need for studies aimed at better describing this uncommon parasitic disease.
dc.language.isoen
dc.publisherElsevier
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshFrance
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshLiver Transplantation
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshProspective Studies
dc.subject.meshQuestionnaires
dc.subject.meshRetrospective Studies
dc.subject.meshAged
dc.subject.meshSeverity of Illness Index
dc.subject.meshYoung Adult
dc.subject.meshAged, 80 and over
dc.subject.meshAnimals
dc.subject.meshAnthelmintics
dc.subject.meshBenzimidazoles
dc.subject.meshEchinococcosis, Hepatic
dc.subject.meshEchinococcus multilocularis
dc.subject.meshFemale
dc.title.enClinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jhep.2011.02.018
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalJournal of Hepatology
bordeaux.page1025-1033
bordeaux.volume55
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.issue5
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-00726569
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00726569v1
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