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Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances

dc.rights.licenseopenen_US
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorENAUD, Raphael
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorHOOKS, Katarzyna B
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorBARRE, Aurelien
dc.contributor.authorBARNETCHE, T.
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorHUBERT, Christophe
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorMASSOT, Marie
dc.contributor.authorBAZIN, T.
dc.contributor.authorCLOUZEAU, H.
dc.contributor.authorBUI, S.
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorFAYON, Michael
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERGER, Patrick
ORCID: 0000-0003-4702-0343
IDREF: 060717998
dc.contributor.authorLEHOURS, Philippe
dc.contributor.authorBEBEAR, Cecile
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorNIKOLSKI, Macha
IDREF: 134506049
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDELHAES, Laurence
dc.contributor.authorSCHAEVERBEKE, Thierry
dc.date.accessioned2020-06-08T10:15:27Z
dc.date.available2020-06-08T10:15:27Z
dc.date.issued2019-05-10
dc.identifier.issn2077-0383 (Print) 2077-0383en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7805
dc.description.abstractEnCystic fibrosis (CF) is a systemic genetic disease that leads to pulmonary and digestive disorders. In the majority of CF patients, the intestine is the site of chronic inflammation and microbiota disturbances. The link between gut inflammation and microbiota dysbiosis is still poorly understood. The main objective of this study was to assess gut microbiota composition in CF children depending on their intestinal inflammation. We collected fecal samples from 20 children with CF. Fecal calprotectin levels were measured and fecal microbiota was analyzed by 16S rRNA sequencing. We observed intestinal inflammation was associated with microbiota disturbances characterized mainly by increased abundances of Staphylococcus, Streptococcus, and Veillonella dispar, along with decreased abundances of Bacteroides, Bifidobacterium adolescentis, and Faecalibacterium prausnitzii. Those changes exhibited similarities with that of Crohn's disease (CD), as evidenced by the elevated CD Microbial-Dysbiosis index that we applied for the first time in CF. Furthermore, the significant over-representation of Streptococcus in children with intestinal inflammation appears to be specific to CF and raises the issue of gut-lung axis involvement. Taken together, our results provide new arguments to link gut microbiota and intestinal inflammation in CF and suggest the key role of the gut-lung axis in the CF evolution.
dc.language.isoENen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.enLEHA
dc.title.enIntestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances
dc.title.alternativeJ Clin Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/jcm8050645en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31083321en_US
bordeaux.journalJ Clin Meden_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=J%20Clin%20Med&rft.date=2019-05-10&rft.volume=8&rft.issue=5&rft.eissn=2077-0383%20(Print)%202077-0383&rft.issn=2077-0383%20(Print)%202077-0383&rft.au=ENAUD,%20Raphael&HOOKS,%20Katarzyna%20B&BARRE,%20Aurelien&BARNETCHE,%20T.&HUBERT,%20Christophe&rft.genre=article


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