In-vitro cartilage growth: macroscopic mass transport modelling in a three-phase system
| hal.structure.identifier | Transferts, écoulements, fluides, énergétique [TREFLE] | |
| dc.contributor.author | LETELLIER, Samuel | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie de Bordeaux [I2M] | |
| dc.contributor.author | AHMADI-SENICHAULT, Azita | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie de Bordeaux [I2M] | |
| dc.contributor.author | LASSEUX, Didier
IDREF: 131294474 | |
| dc.date.accessioned | 2021-05-14T09:55:53Z | |
| dc.date.available | 2021-05-14T09:55:53Z | |
| dc.date.issued | 2009-03-11 | |
| dc.date.conference | 2009-03-11 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/77748 | |
| dc.description.abstractEn | Transplantation of engineered tissues is of major interest as an alternative to autogenic alogenic or exogenic grafts. In this study, in vitro cartilage cell culture on a fibrous biodegradable polymer scaffold is under concern. The scaffold is first seeded with cells which adhere to the fibres and the system is then grown in a bioreactor. As reported in the literature, hydrodynamics and transport of nutrients and metabolic products during this growth process is of considerable importance, motivating our analysis.A one-equation macroscopic model was first developed in order to describe macroscopic mass transport during in vitro tissue growth using the volume averaging method. This model takes into account a three phase system composed of solid fibres, cell phase and fluid phase and allows determination of the macroscopic quantities as a function of microscopic properties and geometry at any stage of growth.In a second step, numerical tools for the computation of the effective properties were developed and validated. This validation is carried out using results available in the literature for some sub-classes of our model (namely, diffusion, diffusion/reaction and diffusion/advection problems in 2D systems). The behaviour of the macroscopic dispersion tensor for the complete model (diffusion/reaction/advection) in a three phase configuration is studied and the influence of different parameters such as the volume fractions of the phases, Peclet and Kinetic numbers is discussed. | |
| dc.language.iso | en | |
| dc.subject.en | Mass transpor | |
| dc.subject.en | Modelling | |
| dc.subject.en | Bioreactor | |
| dc.subject.en | Tissu growth | |
| dc.title.en | In-vitro cartilage growth: macroscopic mass transport modelling in a three-phase system | |
| dc.type | Communication dans un congrès avec actes | |
| dc.subject.hal | Sciences de l'ingénieur [physics]/Mécanique [physics.med-ph]/Mécanique des fluides [physics.class-ph] | |
| bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.institution | INRAE | |
| bordeaux.institution | Arts et Métiers | |
| bordeaux.country | DE | |
| bordeaux.title.proceeding | International Conf. on Challenges of Porous Media | |
| bordeaux.conference.city | Kaiserslautern | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01196737 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01196737v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2009-03-11&rft.au=LETELLIER,%20Samuel&AHMADI-SENICHAULT,%20Azita&LASSEUX,%20Didier&rft.genre=proceeding |
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