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Brain functional plasticity at rest and during action in multiple sclerosis patients

hal.structure.identifierService Neurologie
dc.contributor.authorFAIVRE, Anthony
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorRICO, Audrey
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorZAARAOUI, W
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorREUTER, Francoise
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorCONFORT-GOUNY, Sylviane
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorGUYE, Maxime
hal.structure.identifierPôle de Neurosciences Cliniques, Department of Neurology
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorPELLETIER, Jean
hal.structure.identifierCentre de résonance magnétique biologique et médicale [CRMBM]
dc.contributor.authorRANJEVA, Jean-Philippe
dc.contributor.authorAUDOIN, Bertrand
dc.date.accessioned2021-05-14T09:52:12Z
dc.date.available2021-05-14T09:52:12Z
dc.date.issued2015
dc.identifier.issn0967-5868
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/77430
dc.description.abstractEnAbstract We aimed to demonstrate that basal functional connectivity reorganization observed in a specific network at rest using resting state functional \MRI\ (rs-fMRI) could be associated with functional cortical reorganization in such network during action (ta-fMRI) in a population of early multiple sclerosis (MS) patients. Altered basal functional connectivity has been previously reported in patients with \MS\ but relationships with cortical reorganization during action have not been explored. Thirteen patients with early relapsing-remitting \MS\ and 14 matched healthy controls were explored on a 3T \MRI\ scanner at rest and during a motor task (conjugate finger flexion and extension movements of each hand). Hand motor networks were extracted from rs-fMRI data using group spatial independent component analysis. For the non-dominant motor network, patients presented a higher basal functional connectivity at rest and recruited a supplementary prefrontal cortical area during action compared to the controls. The levels of hyperconnectivity at rest and of activation in the recruited area during action were significantly correlated. No differences were demonstrated for the dominant motor network at rest and during action. The present study, combining rs-fMRI and ta-fMRI in non-disabled patients with early MS, revealed for the first time a direct association between functional reorganization depicted at rest and during action within the same system.
dc.language.isoen
dc.publisherElsevier
dc.subject.enResting state
dc.title.enBrain functional plasticity at rest and during action in multiple sclerosis patients
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jocn.2015.02.033
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
bordeaux.journalJournal of Clinical Neuroscience
bordeaux.page1438 -- 1443
bordeaux.volume22
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-01419492
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01419492v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Neuroscience&rft.date=2015&rft.volume=22&rft.issue=9&rft.spage=1438%20--%201443&rft.epage=1438%20--%201443&rft.eissn=0967-5868&rft.issn=0967-5868&rft.au=FAIVRE,%20Anthony&RICO,%20Audrey&ZAARAOUI,%20W&REUTER,%20Francoise&CONFORT-GOUNY,%20Sylviane&rft.genre=article


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