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Impact of copper nanoparticles on porcine neutrophils: Proposition of an ultrasensitive characterization factor using chemiluminescence information and USEtox assessment model

hal.structure.identifierLaboratoire de Nanotechnologie et d'Instrumentation Optique [LNIO]
hal.structure.identifierCentre de Recherches et d'Etudes Interdisciplinaires sur le Développement Durable [CREIDD]
dc.contributor.authorPU, Yubing
hal.structure.identifierCentre de Recherches et d'Etudes Interdisciplinaires sur le Développement Durable [CREIDD]
dc.contributor.authorLARATTE, Bertrand
IDREF: 181621169
hal.structure.identifierBen-Gurion University of the Negev [BGU]
dc.contributor.authorMARKS, Robert
hal.structure.identifierLaboratoire de Nanotechnologie et d'Instrumentation Optique [LNIO]
dc.contributor.authorIONESCU, Rodica Elena
dc.date.accessioned2021-05-14T09:51:43Z
dc.date.available2021-05-14T09:51:43Z
dc.date.issued2017
dc.identifier.issn2352-4928
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/77384
dc.description.abstractEnThere is a need by the European Commission (EC) regulations, as well as others, to reduce the in vivo toxicity tests made on animals. Conventional in vitro tests were designed for non-nanoparticle sized entities, and therefore do not necessarily assess the adverse impacts of engineered nanoparticles (ENPs) on humans. Life cycle assessment (LCA) is a widely used methodology for evaluating the environmental performance of products. Nevertheless, the application of LCA on ENPs is difficult because the characterization factors (CFs) of ENPs, as significant input parameters in LCA, remain a major unknown. It is a premise of this study to monitor the chemiluminescence (CL) spectra resulting from the reactive oxygen species (ROS) trigger made from the presence of copper nanoparticles (CuNPs) to porcine neutrophils in vitro, thereby enabling to calculate the porcine and human toxicity CFs. The framework of a scientific consensus model, USEtox model, is selected and the midpoint of CF is set as the inflammation of pig or human. Finally, the present study recommends human and porcine inflammation CFs of CuNPs in Europe to be 1.07 and 2.90 CTU (comparative toxic units) respectively.
dc.language.isoen
dc.publisherElsevier
dc.subject.enCopper nanoparticles
dc.subject.enUSEtox model
dc.subject.enCharacterization factor
dc.subject.enPorcine neutrophils
dc.subject.enin vitro chemiluminescence
dc.title.enImpact of copper nanoparticles on porcine neutrophils: Proposition of an ultrasensitive characterization factor using chemiluminescence information and USEtox assessment model
dc.typeArticle de revue
dc.identifier.doi10.1016/j.mtcomm.2017.02.008
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie
dc.subject.halSciences de l'environnement/Ingénierie de l'environnement
bordeaux.journalMaterials Today Communications
bordeaux.page68-75
bordeaux.volume11
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.peerReviewedoui
hal.identifierhal-01489194
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01489194v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Materials%20Today%20Communications&rft.date=2017&rft.volume=11&rft.spage=68-75&rft.epage=68-75&rft.eissn=2352-4928&rft.issn=2352-4928&rft.au=PU,%20Yubing&LARATTE,%20Bertrand&MARKS,%20Robert&IONESCU,%20Rodica%20Elena&rft.genre=article


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