Dendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | JIANG, Jian-Qiao | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CHANSEAU, Christel | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | ALVES, Isabel | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | NLATE, Sylvain | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | DURRIEU, Marie-Christine | |
| dc.date.accessioned | 2020-05-18T15:27:06Z | |
| dc.date.available | 2020-05-18T15:27:06Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 2589-0042 | en_US |
| dc.identifier.other | https://doi.org/10.1016/j.isci.2019.10.014 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7623 | |
| dc.description.abstractEn | Microvesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated analysis including morphological, quantitative, and compositional studies is most desirable for the clinical application of MV detection; however, such integration is limited by the currently available analysis techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic molecules with PS-binding sites at the periphery. PS-dendron binding was studied at the molecular level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Chemistry | |
| dc.subject.en | Supramolecular Chemistry | |
| dc.subject.en | Surface Science | |
| dc.title.en | Dendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.isci.2019.10.014 | |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | iScience | en_US |
| bordeaux.page | 110-123 | en_US |
| bordeaux.volume | 21 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03160460 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-26T10:07:19Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=iScience&rft.date=2019&rft.volume=21&rft.spage=110-123&rft.epage=110-123&rft.eissn=2589-0042&rft.issn=2589-0042&rft.au=JIANG,%20Jian-Qiao&CHANSEAU,%20Christel&ALVES,%20Isabel&NLATE,%20Sylvain&DURRIEU,%20Marie-Christine&rft.genre=article |
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