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Dendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorJIANG, Jian-Qiao
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCHANSEAU, Christel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorALVES, Isabel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorNLATE, Sylvain
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDURRIEU, Marie-Christine
dc.date.accessioned2020-05-18T15:27:06Z
dc.date.available2020-05-18T15:27:06Z
dc.date.issued2019
dc.identifier.issn2589-0042en_US
dc.identifier.otherhttps://doi.org/10.1016/j.isci.2019.10.014en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7623
dc.description.abstractEnMicrovesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated analysis including morphological, quantitative, and compositional studies is most desirable for the clinical application of MV detection; however, such integration is limited by the currently available analysis techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic molecules with PS-binding sites at the periphery. PS-dendron binding was studied at the molecular level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses.
dc.language.isoENen_US
dc.subject.enChemistry
dc.subject.enSupramolecular Chemistry
dc.subject.enSurface Science
dc.title.enDendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.isci.2019.10.014
dc.subject.halChimie/Matériauxen_US
bordeaux.journaliScienceen_US
bordeaux.page110-123en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03160460
hal.version1
hal.date.transferred2021-03-26T10:07:19Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=iScience&rft.date=2019&rft.volume=21&rft.spage=110-123&rft.epage=110-123&rft.eissn=2589-0042&rft.issn=2589-0042&rft.au=JIANG,%20Jian-Qiao&CHANSEAU,%20Christel&ALVES,%20Isabel&NLATE,%20Sylvain&DURRIEU,%20Marie-Christine&rft.genre=article


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