Role of mechanical cues and hypoxia on the growth of tumor cells in strong and weak confinement: A dual in vitro–in silico approach
hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
dc.contributor.author | LE MAOUT, V. | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | ALESSANDRI, K. | |
hal.structure.identifier | Sorbonne Université [SU] | |
hal.structure.identifier | Institut du Cerveau = Paris Brain Institute [ICM] | |
dc.contributor.author | GURCHENKOV, B. | |
hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
dc.contributor.author | BERTIN, Henri
IDREF: 069375607 | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | NASSOY, P. | |
hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
dc.contributor.author | SCIUME, Giuseppe
IDREF: 170950476 | |
dc.date.accessioned | 2021-05-14T09:35:27Z | |
dc.date.available | 2021-05-14T09:35:27Z | |
dc.date.issued | 2020-03-25 | |
dc.identifier.issn | 2375-2548 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/76211 | |
dc.description.abstractEn | Characterization of tumor growth dynamics is of major importance for cancer understanding. By contrast with phenomenological approaches, mechanistic modeling can facilitate disclosing underlying tumor mechanisms and lead to identification of physical factors affecting proliferation and invasive behavior. Current mathematical models are often formulated at the tissue or organ scale with the scope of a direct clinical usefulness. Consequently, these approaches remain empirical and do not allow gaining insight into the tumor properties at the scale of small cell aggregates. Here, experimental and numerical studies of the dynamics of tumor aggregates are performed to propose a physics-based mathematical model as a general framework to investigate tumor microenvironment. The quantitative data extracted from the cellular capsule technology microfluidic experiments allow a thorough quantitative comparison with in silico experiments. This dual approach demonstrates the relative impact of oxygen and external mechanical forces during the time course of tumor model progression. | |
dc.description.sponsorship | Nouvelles voies de formation de vaisseaux sanguins et lymphatiques: Development d'un système d'encapsulation et l'etude de l'impact des forces mécaniques sur les mécanismes de régulation cellulaires et moléculaires - ANR-15-CE18-0019 | |
dc.language.iso | en | |
dc.publisher | American Association for the Advancement of Science (AAAS) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/ | |
dc.title.en | Role of mechanical cues and hypoxia on the growth of tumor cells in strong and weak confinement: A dual in vitro–in silico approach | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1126/sciadv.aaz7130 | |
dc.subject.hal | Sciences du Vivant [q-bio] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
bordeaux.journal | Science Advances | |
bordeaux.page | eaaz7130 | |
bordeaux.volume | 6 | |
bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | * |
bordeaux.issue | 13 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.institution | INRAE | |
bordeaux.institution | Arts et Métiers | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02552525 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02552525v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2020-03-25&rft.volume=6&rft.issue=13&rft.spage=eaaz7130&rft.epage=eaaz7130&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=LE%20MAOUT,%20V.&ALESSANDRI,%20K.&GURCHENKOV,%20B.&BERTIN,%20Henri&NASSOY,%20P.&rft.genre=article |
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