1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD)
| dc.rights.license | open | en_US |
| dc.relation.isnodouble | b5324c18-82cf-442e-acda-e23e977e57de | * |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BAUDIN, Antoine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GUICHARD, Anne | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | COLLIE, Gavin W. | |
| hal.structure.identifier | ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle | |
| dc.contributor.author | ROUSSEAU, Sabrina | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CHAIGNEPAIN, Stephane | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | HOCQUELLET, Agnes | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BERBON, Melanie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LOQUET, Antoine | |
| hal.structure.identifier | ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle | |
| dc.contributor.author | MACKERETH, Cameron | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GUICHARD, Gilles
IDREF: 084339268 | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | ODAERT, Benoit | |
| dc.date.accessioned | 2020-04-17T10:11:21Z | |
| dc.date.available | 2020-04-17T10:11:21Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1874-2718 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/4295 | |
| dc.description.abstractEn | Death receptors (DR) selectively drive cancer cells to apoptosis upon binding to the Tumor necrosis factor-a-Related Apoptosis-Inducing Ligand (TRAIL). Complex formation induces the oligomerization of the death receptors DR4 (TRAIL-R1) and DR5 (TRAIL-R2) and transduces the apoptogenic signal to their respective death domains, leading to Death Inducing Signaling Complex (DISC) formation, caspase activation and ultimately cell death. Several crystal structures of the ExtraCellular Domain from Death Receptor 5 (DR5-ECD) have been reported in complex with the TRAIL ligand or anti-DR5 antibodies, but none for the isolated protein. In order to fill this gap and to perform binding experiments with TRAIL peptidomimetics, we have produced isotopically labelled DR5-ECD and started a conformational analysis by using high-field 3D NMR spectroscopy. Herein, we present the first resonance assignment of a TRAIL receptor in solution and the determination of its secondary structure from NMR chemical shifts. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | DR5 | |
| dc.subject.en | TRAIL | |
| dc.subject.en | Cancer | |
| dc.subject.en | Apoptosis | |
| dc.subject.en | NMR spectroscopy | |
| dc.subject.en | Resonance assignment | |
| dc.subject.en | Secondary structure | |
| dc.title.en | 1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD) | |
| dc.title.alternative | Biomol NMR Assign | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s12104-018-9828-1 | |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Biomolecular Nmr Assignments | en_US |
| bordeaux.page | 309-314 | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
| hal.identifier | hal-03184395 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-29T12:21:27Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomolecular%20Nmr%20Assignments&rft.date=2018&rft.volume=12&rft.issue=2&rft.spage=309-314&rft.epage=309-314&rft.eissn=1874-2718&rft.issn=1874-2718&rft.au=BAUDIN,%20Antoine&GUICHARD,%20Anne&COLLIE,%20Gavin%20W.&ROUSSEAU,%20Sabrina&CHAIGNEPAIN,%20Stephane&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||