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Tissular Distribution and Metabolism of trans-epsilon-Viniferin after Intraperitoneal Injection in Rat

dc.rights.licenseopenen_US
dc.relation.isnodoubleee8c8fc6-9149-40f8-a2ca-181952001594*
dc.relation.isnodouble6ddf6c55-c2dd-4884-ac24-1fe7dd5f14fa*
dc.relation.isnodoublefd936fb8-8093-4c8f-ac1a-efcb9b585d7b*
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorCOURTOIS, Arnaud
IDREF: 092021301
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorATGIE, Claude
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMARCHAL, Axel
IDREF: 150146477
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorHORNEDO ORTEGA, Ruth
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorLAPEZE, Caroline
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFAURE, Chrystel
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
dc.date.accessioned2020-04-15T12:57:33Z
dc.date.available2020-04-15T12:57:33Z
dc.date.issued2018
dc.identifier.issn2072-6643en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/4283
dc.description.abstractEnBackground: Recent studies showed that trans-epsilon-viniferin (epsilon-viniferin), a trans-resveratrol dehydrodimer, has anti-inflammatory and anti-obesity effects in rodents. The main purpose of this work was to assess the tissue distribution study of epsilon-viniferin and its metabolites after intraperitoneal (IP) administration in rat. Methods: After IP injection of 50 mg/kg, epsilon-viniferin and its metabolites were identified and quantified in plasma, liver, kidneys, adipose tissues, urine, and faeces by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS). Results: epsilon-Viniferin underwent a rapid hepatic metabolism mostly to glucuronides but also to a lesser extent to sulphate derivatives. The highest glucuronide concentrations were found in liver followed by plasma and kidneys whereas only traces amounts were found in adipose tissues. In contrast the highest epsilon-viniferin areas under concentration (AUC) and mean residence times (MRT) values were found in white adipose tissues. Finally, much lower levels of epsilon-viniferin or its metabolites were found in urine than in faeces, suggesting that biliary excretion is the main elimination pathway. Conclusion: A rapid and large metabolism of epsilon-viniferin and a high bioaccumulation in white adipose tissues were observed. Thus, these tissues could be a reservoir of the native form of epsilon-viniferin that could allow its slow release and a sustained presence within the organism.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.subject.enε-viniferin
dc.subject.endistribution
dc.subject.enmetabolism
dc.subject.enadipose tissue
dc.title.enTissular Distribution and Metabolism of trans-epsilon-Viniferin after Intraperitoneal Injection in Rat
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/nu10111660en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalNutrientsen_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue11en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02543635
hal.version1
hal.date.transferred2020-04-15T12:57:39Z
hal.exporttrue
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