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Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

dc.rights.licenseopenen_US
dc.contributor.authorFARIDI, Ava
dc.contributor.authorSUN, Yunxiang
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorOKAZAKI, Yutaka
dc.contributor.authorPENG, Guotao
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorGAO, Jie
dc.contributor.authorKAKINEN, Aleksandr
dc.contributor.authorFARIDI, Pouya
dc.contributor.authorZHAO, Mei
dc.contributor.authorJAVED, Ibrahim
dc.contributor.authorPURCELL, Anthony W.
dc.contributor.authorDAVIS, Thomas P.
dc.contributor.authorLIN, Sijie
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorODA, Reiko
dc.contributor.authorDING, Feng
dc.contributor.authorKE, Pu Chun
dc.date.accessioned2020-04-10T09:39:55Z
dc.date.available2020-04-10T09:39:55Z
dc.date.issued2018
dc.identifier.issn1613-6810en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/4222
dc.description.abstractEnAmyloid fibrils generally display chirality, a feature which has rarely been exploited in the development of therapeutics against amyloid diseases. This study reports, for the first time, the use of mesoscopic chiral silica nanoribbons against the in vivo amyloidogenesis of human islet amyloid polypeptide (IAPP), the peptide whose aggregation is implicated in type 2 diabetes. The thioflavin T assay and transmission electron microscopy show accelerated IAPP fibrillization through elimination of the nucleation phase and shortening of the elongation phase by the nanostructures. Coarse-grained simulations offer complementary molecular insights into the acceleration of amyloid aggregation through their nonspecific binding and directional seeding with the nanostructures. This accelerated IAPP fibrillization translates to reduced toxicity, especially for the right-handed silica nanoribbons, as revealed by cell viability, helium ion microscopy, as well as zebrafish embryo survival, developmental, and behavioral assays. This study has implicated the potential of employing chiral nanotechnologies against the mesoscopic enantioselectivity of amyloid proteins and their associated diseases.
dc.language.isoENen_US
dc.subject.enhuman IAPP
dc.subject.ensilica nanoribbons
dc.subject.enchirality
dc.subject.entoxicity
dc.subject.enamyloidogenesis
dc.title.enMitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/smll.201802825
dc.subject.halChimie/Matériauxen_US
dc.identifier.pubmed30369028en_US
bordeaux.journalSmallen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue47en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03184345
hal.version1
hal.date.transferred2021-03-29T11:48:58Z
hal.exporttrue
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