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Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA
| dc.rights.license | open | en_US |
| dc.relation.isnodouble | db89e9d0-44fb-470b-bd57-d7ba31aa6d0a | * |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | ZIACH, Krzysztof | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CHOLLET, Celine | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PARISSI, Vincent | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | PRABHAKARAN, Panchami | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | MARCHIVIE, Mathieu | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CORVAGLIA, Valentina | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BOSE, Partha Pratim | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LAXMI-REDDY, Katta | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GODDE, Frederic | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | SCHMITTER, Jean-Marie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CHAIGNEPAIN, Stephane | |
| dc.contributor.author | POURQUIER, Philippe | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | HUC, Ivan | |
| dc.date.accessioned | 2020-04-08T07:52:54Z | |
| dc.date.available | 2020-04-08T07:52:54Z | |
| dc.date.created | 2018 | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1755-4330 | en_US |
| dc.identifier.other | https://static-content.springer.com/esm/art%3A10.1038%2Fs41557-018-0018-7/MediaObjects/41557_2018_18_MOESM3_ESM.mp4 | en_US |
| dc.identifier.other | https://static-content.springer.com/esm/art%3A10.1038%2Fs41557-018-0018-7/MediaObjects/41557_2018_18_MOESM1_ESM.pdf | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/4156 | |
| dc.description.abstractEn | Numerous essential biomolecular processes require the recognition of DNA surface features by proteins. Molecules mimicking these features could potentially act as decoys and interfere with pharmacologically or therapeutically relevant protein-DNA interactions. Although naturally occurring DNA-mimicking proteins have been described, synthetic tunable molecules that mimic the charge surface of double-stranded DNA are not known. Here, we report the design, synthesis and structural characterization of aromatic oligoamides that fold into single helical conformations and display a double helical array of negatively charged residues in positions that match the phosphate moieties in B-DNA. These molecules were able to inhibit several enzymes possessing non-sequence-selective DNA-binding properties, including topoisomerase 1 and HIV-1 integrase, presumably through specific foldamer-protein interactions, whereas sequence-selective enzymes were not inhibited. Such modular and synthetically accessible DNA mimics provide a versatile platform to design novel inhibitors of protein-DNA interactions. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Chemical tools | |
| dc.subject.en | DNA-binding proteins | |
| dc.subject.en | Nucleic acids | |
| dc.title.en | Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA | |
| dc.title.alternative | Nature Chem | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41557-018-0018-7 | |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Nature Chemistry | en_US |
| bordeaux.page | 511-518 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03180111 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-24T16:36:21Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Chemistry&rft.date=2018&rft.volume=10&rft.issue=5&rft.spage=511-518&rft.epage=511-518&rft.eissn=1755-4330&rft.issn=1755-4330&rft.au=ZIACH,%20Krzysztof&CHOLLET,%20Celine&PARISSI,%20Vincent&PRABHAKARAN,%20Panchami&MARCHIVIE,%20Mathieu&rft.genre=article |
