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Prefrontal activity during experimental ostracism and daily psychache in suicide attempters

dc.rights.licenseopenen_US
dc.contributor.authorOLIE, Emilie
hal.structure.identifierLaboratoire de psychologie [LabPsy]
dc.contributor.authorHUSKY, Mathilde
IDREF: 079957668
dc.contributor.authorLE BARS, Emmanuelle
dc.contributor.authorDEVERDUN, Jeremy
dc.contributor.authorMENJOT DE CHAMPFLEUR, Nicolas
dc.contributor.authorCRESPO, Adrian Alacreu
dc.contributor.authorSWENDSEN, Joel
dc.contributor.authorCOURTET, Philippe
dc.date.accessioned2021-04-06T13:54:41Z
dc.date.available2021-04-06T13:54:41Z
dc.date.issued2021-02-09
dc.identifier.issn0165-0327en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26876
dc.description.abstractEnBACKGROUND: Suicidal behaviors can result from a complex interaction between social stressors and individual vulnerability. Evidence suggests a specific neural processing of social cues in suicide attempters without knowledge of how it relates to real-world experiences. OBJECTIVE: To investigate the association between brain activity during experimental social exclusion (measured by functional MRI) and psychological pain in daily life (assessed by Ecological Momentary Assessment) in patients with a lifetime history of suicide attempt. METHODS: Thirty-three euthymic females with a history of a major depressive episode were recruited: 13 suicide attempters and 20 affective controls (no history of suicide attempt). Functional MRI scans were acquired while participants played the Cyberball game, a validated social exclusion paradigm. After fMRI, participants completed EMA for a one-week period. Five times per day, they were asked to rate their psychological pain, hopelessness and the negativity of daily events. EMA indices (psychological pain, hopelessness and their interaction with negative events) were correlated with cerebral activations using a ROI approach (orbitofrontal, dorsal and ventrolateral prefrontal cortices, anterior cingulate cortex and insula) in each group. RESULTS: We found a negative correlation between daily ratings of psychological pain and orbitofrontal activation for exclusion versus inclusion during the Cyberball game in suicide attempters but not in affective controls. We did not find correlations between cerebral activation and daily hopelessness ratings. LIMITATIONS: Small sample size CONCLUSION: Scanner-based orbitofrontal activity during social exclusion relates to psychological pain in daily life which participates in suicide risk among vulnerable individuals.
dc.language.isoENen_US
dc.subject.enSocial exclusion
dc.subject.enEcological momentary assessment
dc.subject.enPsychological pain
dc.subject.enSuicide
dc.subject.enfMRI
dc.title.enPrefrontal activity during experimental ostracism and daily psychache in suicide attempters
dc.title.alternativeJ Affect Disorden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2021.01.087en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33636672en_US
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page63–68en_US
bordeaux.volume285en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.audienceInternationale
hal.exportfalse
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