dearseq: a variance component score test for RNA-seq differential analysis that effectively controls the false discovery rate
| dc.rights.license | open | en_US |
| dc.contributor.author | GAUTHIER, Marine | |
| dc.contributor.author | AGNIEL, Denis | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | THIEBAUT, Rodolphe | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HEJBLUM, Boris
ORCID: 0000-0003-0646-452X IDREF: 189970316 | |
| dc.date.accessioned | 2021-03-30T15:01:16Z | |
| dc.date.available | 2021-03-30T15:01:16Z | |
| dc.date.issued | 2020-11-19 | |
| dc.identifier.issn | 2631-9268 | en_US |
| dc.identifier.uri | oai:crossref.org:10.1093/nargab/lqaa093 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26840 | |
| dc.description.abstractEn | Abstract RNA-seq studies are growing in size and popularity. We provide evidence that the most commonly used methods for differential expression analysis (DEA) may yield too many false positive results in some situations. We present dearseq, a new method for DEA that controls the false discovery rate (FDR) without making any assumption about the true distribution of RNA-seq data. We show that dearseq controls the FDR while maintaining strong statistical power compared to the most popular methods. We demonstrate this behavior with mathematical proofs, simulations and a real data set from a study of tuberculosis, where our method produces fewer apparent false positives. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.source | crossref | |
| dc.title.en | dearseq: a variance component score test for RNA-seq differential analysis that effectively controls the false discovery rate | |
| dc.title.alternative | NAR Genom Bioinform | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/nargab/lqaa093 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33575637 | en_US |
| bordeaux.journal | NAR Genomics and Bioinformatics | en_US |
| bordeaux.page | lqaa093 | en_US |
| bordeaux.volume | 2 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SISTM_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.export | false | |
| workflow.import.source | dissemin | |
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