Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases.
| dc.rights.license | open | en_US |
| dc.contributor.author | JOSEFSSON, Emma C | |
| dc.contributor.author | VAINCHENKER, William | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | JAMES, Chloe | |
| dc.date.accessioned | 2021-03-22T11:12:33Z | |
| dc.date.available | 2021-03-22T11:12:33Z | |
| dc.date.issued | 2020-10-14 | |
| dc.identifier.issn | 1422-0067 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26766 | |
| dc.description.abstractEn | Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the prosurvival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 France (CC BY 3.0 FR) | |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/fr/ | |
| dc.subject.en | Animals | |
| dc.subject.en | Apoptosis | |
| dc.subject.en | Blood Platelet Disorders | |
| dc.subject.en | Blood Platelets | |
| dc.subject.en | Humans | |
| dc.subject.en | Megakaryocytes | |
| dc.subject.en | Thrombopoiesis | |
| dc.subject.en | bcl-X Protein | |
| dc.title.en | Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases. | |
| dc.title.alternative | Int J Mol Sci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/ijms21207591 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire | en_US |
| dc.identifier.pubmed | 33066573 | en_US |
| bordeaux.journal | International Journal of Molecular Sciences | en_US |
| bordeaux.volume | 21 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires - U1034 | en_US |
| bordeaux.issue | 20 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03176352 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-05-11T09:44:53Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
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