PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
dc.rights.license | open | en_US |
dc.contributor.author | KLEINEIDAM, L. | |
dc.contributor.author | CHOURAKI, V. | |
dc.contributor.author | PROCHNICKI, T. | |
dc.contributor.author | VAN DER LEE, S. J. | |
dc.contributor.author | MADRID-MARQUEZ, L. | |
dc.contributor.author | WAGNER-THELEN, H. | |
dc.contributor.author | KARACA, I. | |
dc.contributor.author | WEINHOLD, L. | |
dc.contributor.author | WOLFSGRUBER, S. | |
dc.contributor.author | BOLAND, A. | |
dc.contributor.author | MARTINO ADAMI, P. V. | |
dc.contributor.author | LEWCZUK, P. | |
dc.contributor.author | POPP, J. | |
dc.contributor.author | BROSSERON, F. | |
dc.contributor.author | JANSEN, I. E. | |
dc.contributor.author | HULSMAN, M. | |
dc.contributor.author | KORNHUBER, J. | |
dc.contributor.author | PETERS, O. | |
dc.contributor.author | BERR, C. | |
dc.contributor.author | HEUN, R. | |
dc.contributor.author | FROLICH, L. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TZOURIO, Christophe
IDREF: 69829209 | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DARTIGUES, Jean-Francois | |
dc.contributor.author | HULL, M. | |
dc.contributor.author | ESPINOSA, A. | |
dc.contributor.author | HERNANDEZ, I. | |
dc.contributor.author | DE ROJAS, I. | |
dc.contributor.author | ORELLANA, A. | |
dc.contributor.author | VALERO, S. | |
dc.contributor.author | STRINGA, N. | |
dc.contributor.author | VAN SCHOOR, N. M. | |
dc.contributor.author | HUISMAN, M. | |
dc.contributor.author | SCHELTENS, P. | |
dc.contributor.author | ALZHEIMER'S DISEASE NEUROIMAGING, Initiative | |
dc.contributor.author | RUTHER, E. | |
dc.contributor.author | DELEUZE, J. F. | |
dc.contributor.author | WILTFANG, J. | |
dc.contributor.author | TARRAGA, L. | |
dc.contributor.author | SCHMID, M. | |
dc.contributor.author | SCHERER, M. | |
dc.contributor.author | RIEDEL-HELLER, S. | |
dc.contributor.author | HENEKA, M. T. | |
dc.contributor.author | AMOUYEL, Philippe | |
dc.contributor.author | JESSEN, F. | |
dc.contributor.author | BOADA, M. | |
dc.contributor.author | MAIER, W. | |
dc.contributor.author | SCHNEIDER, A. | |
dc.contributor.author | GONZALEZ-PEREZ, A. | |
dc.contributor.author | VAN DER FLIER, W. M. | |
dc.contributor.author | WAGNER, M. | |
dc.contributor.author | LAMBERT, J. C. | |
dc.contributor.author | HOLSTEGE, H. | |
dc.contributor.author | SAEZ, M. E. | |
dc.contributor.author | LATZ, E. | |
dc.contributor.author | RUIZ, A. | |
dc.contributor.author | RAMIREZ, A. | |
dc.date.accessioned | 2021-02-24T10:37:37Z | |
dc.date.available | 2021-02-24T10:37:37Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1432-0533 (Electronic) 0001-6322 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26338 | |
dc.description.abstractEn | pinnings, we identified a network of co-expressed proteins connecting PLCG2 to APOE and TREM2 using unsupervised co-regulatory network analysis. The network was highly enriched for the complement cascade and genes differentially expressed in disease-associated microglia. Our data show that p.P522R in PLCG2 reduces AD disease progression by mitigating tau pathology in the presence of amyloid pathology and, as a consequence, maintains cognitive function. Targeting the enzyme PLCG2 might provide a new therapeutic approach for treating AD. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | SEPIA | |
dc.subject | HEALTHY | |
dc.title.en | PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment | |
dc.title.alternative | Acta Neuropathol | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1007/s00401-020-02138-6 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 32166339 | en_US |
bordeaux.journal | Acta Neuropathologica | en_US |
bordeaux.page | 1025-1044 | en_US |
bordeaux.volume | 139 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
bordeaux.issue | 6 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | SEPIA | en_US |
bordeaux.team | HEALTHY_BPH | |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03150932 | |
hal.version | 1 | |
hal.date.transferred | 2021-02-24T10:37:44Z | |
hal.export | true | |
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