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dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorAGUT, Willy
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorAGNAOU, Reda
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorTATON, Daniel
dc.date.accessioned2020
dc.date.available2020
dc.date.created2008
dc.date.issued2008
dc.identifier.issn1022-1336
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20792
dc.description.abstractEnA novel synthetic methodology to diblock copolypeptides was developed by ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs) from alpha-omega-functionalized initiators combined with the Huisgen 1,3 dipolar cycloaddition (click chemistry). Poly(gamma-benzyl-L-glutamate) (PBLGlu) and poly(trifluoroacetyl-L-Lysine) (PTFALys) containing either an azide or an alkyne functional group in alpha-position were first synthesized by ROP of the corresponding NCA at room temperature in DMF as a solvent, using appropriate omega-amino-containing alpha-alkyne and a-azido difunctional initiators. The Copper(I) -catalyzed coupling reactions of alpha-azido-PBLGlu with the alpha-alkyne-PTFALys, on the one hand, and of the alpha-alkyne-PBLGlu with the alpha-azido-PTFALys, on the other hand were suitably accomplished in DMF. This afforded the targeted PBLGlu-b-PTFALys diblock copolypeptides pos- sessing a triazole group in between the two 1 blocks, as evidenced by SEC, IR, and NMR analysis. Block copolypeptides could be successfully purified by selective extraction with chloroform.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.subject.enL-LYSINE
dc.subject.enL-LEUCINE
dc.subject.enMODULAR SYNTHESIS
dc.subject.enONE-POT SYNTHESIS
dc.subject.enL-GLUTAMIC ACID
dc.subject.enROD-COIL
dc.subject.enTRIBLOCK COPOLYMERS
dc.subject.enDIBLOCK COPOLYMERS
dc.subject.enMATERIALS SCIENCE
dc.subject.enPOLYPEPTIDE
dc.title.enSynthesis of block copolypeptides by click chemistry
dc.typeArticle de revue
dc.identifier.doi10.1002/marc.200800123
dc.subject.halChimie/Polymères
bordeaux.journalMacromolecular Rapid Communications
bordeaux.page1147-1155
bordeaux.volume29
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue12-13
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00338937
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00338937v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecular%20Rapid%20Communications&rft.date=2008&rft.volume=29&rft.issue=12-13&rft.spage=1147-1155&rft.epage=1147-1155&rft.eissn=1022-1336&rft.issn=1022-1336&rft.au=AGUT,%20Willy&AGNAOU,%20Reda&LECOMMANDOUX,%20Sebastien&TATON,%20Daniel&rft.genre=article


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