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Preferential crystallization assisted by supercritical CO2
| dc.rights.license | open | en_US |
| dc.contributor.author | DE MEESTER, Josephine | |
| dc.contributor.author | LEYSSENS, Tom | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | HARSCOAT-SCHIAVO, Christelle | |
| dc.date.accessioned | 2025-10-20T13:03:11Z | |
| dc.date.available | 2025-10-20T13:03:11Z | |
| dc.date.issued | 2024-07 | |
| dc.date.conference | 2024-07-23 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207846 | |
| dc.description.abstractEn | Preferential crystallization is a kinetic separation technique limited to chiral molecules that crystallize as conglomerates. The technique relies on a difference in crystallization rates of enantiomers in the presence of enantiopure seeding.1,-3 Here, we are the first to employ supercritical carbon dioxide (SC-CO2) to assist preferential crystallization. We do so, focusing on the nefiracetam-mandelic acid cocrystal system (Fig. 1), previously resolved by classical preferential crystallization3. The increased interest in SC-CO2 reflects a growing interest in replacing conventional organic solvents known for their environmental drawbacks. SC-CO2 presents an appealing alternative, given its environmentally friendly properties, including non-toxicity, non-flammability, chemical inertness, and recyclability through pressure reduction.4,5 As research on SC-CO2 expands, our study aims to contribute to the understanding of its potential in chiral resolution. While prior investigations have successfully utilized SC-CO2 for resolution through diastereoisomeric formation6-9, we here, are the first to showcase its potential in preferential crystallization. | |
| dc.description.sponsorship | Apport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Chirality | |
| dc.subject.en | Preferential crystallization | |
| dc.subject.en | Supercritical CO2 | |
| dc.title.en | Preferential crystallization assisted by supercritical CO2 | |
| dc.type | Communication dans un congrès | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.conference.title | 15th International Workshop on Crystal Growth of Organic Materials - CGOM 15 | en_US |
| bordeaux.country | th | en_US |
| bordeaux.conference.city | Phuket | en_US |
| hal.proceedings | oui | en_US |
| hal.conference.organizer | Suranaree University of Technology | en_US |
| hal.conference.end | 2024-07-26 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2024-07&rft.au=DE%20MEESTER,%20Josephine&LEYSSENS,%20Tom&HARSCOAT-SCHIAVO,%20Christelle&rft.genre=unknown |