Preferential crystallization assisted by supercritical CO2
Language
EN
Communication dans un congrès
This item was published in
15th International Workshop on Crystal Growth of Organic Materials - CGOM 15, 2024-07-23, Phuket. 2024-07
English Abstract
Preferential crystallization is a kinetic separation technique limited to chiral molecules that crystallize as conglomerates. The technique relies on a difference in crystallization rates of enantiomers in the presence of ...Read more >
Preferential crystallization is a kinetic separation technique limited to chiral molecules that crystallize as conglomerates. The technique relies on a difference in crystallization rates of enantiomers in the presence of enantiopure seeding.1,-3 Here, we are the first to employ supercritical carbon dioxide (SC-CO2) to assist preferential crystallization. We do so, focusing on the nefiracetam-mandelic acid cocrystal system (Fig. 1), previously resolved by classical preferential crystallization3. The increased interest in SC-CO2 reflects a growing interest in replacing conventional organic solvents known for their environmental drawbacks. SC-CO2 presents an appealing alternative, given its environmentally friendly properties, including non-toxicity, non-flammability, chemical inertness, and recyclability through pressure reduction.4,5 As research on SC-CO2 expands, our study aims to contribute to the understanding of its potential in chiral resolution. While prior investigations have successfully utilized SC-CO2 for resolution through diastereoisomeric formation6-9, we here, are the first to showcase its potential in preferential crystallization.Read less <
English Keywords
Chirality
Preferential crystallization
Supercritical CO2
ANR Project
Apport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047