Deciphering the singularity of autophagic membranes: key lipids in autophagy
BATSALE, Marguerite
Biologie du fruit et pathologie [BFP]
MetaboHUB
Laboratoire de biogenèse membranaire [LBM]
Biologie du fruit et pathologie [BFP]
MetaboHUB
Laboratoire de biogenèse membranaire [LBM]
GROS, V
Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
Physiologie cellulaire et végétale [LPCV]
Institut de recherche biomédicale des armées. Antenne Grenoble [IRBA [Grenoble]]
Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
Physiologie cellulaire et végétale [LPCV]
Institut de recherche biomédicale des armées. Antenne Grenoble [IRBA [Grenoble]]
HÉRICÉ, Charlotte
Université de Bordeaux [UB]
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Mnemonic Synergy [Mnemosyne]
Université de Bordeaux [UB]
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Mnemonic Synergy [Mnemosyne]
GENVA, Manon
Laboratoire de biogenèse membranaire [LBM]
Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich [ULiège]
Laboratoire de biogenèse membranaire [LBM]
Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich [ULiège]
JOUBÈS, Jérôme
Université de Bordeaux [UB]
Centre National de la Recherche Scientifique [CNRS]
Laboratoire de biogenèse membranaire [LBM]
< Réduire
Université de Bordeaux [UB]
Centre National de la Recherche Scientifique [CNRS]
Laboratoire de biogenèse membranaire [LBM]
Langue
en
Communication dans un congrès
Ce document a été publié dans
Gordon Research Seminar, 2025-01-16, Lucca.
Résumé en anglais
Autophagy is an intracellular mechanism that enables eukaryotes to respond adaptively to environmental stress by promoting degradation and recycling of cell components. This process relies on intense membrane remodeling ...Lire la suite >
Autophagy is an intracellular mechanism that enables eukaryotes to respond adaptively to environmental stress by promoting degradation and recycling of cell components. This process relies on intense membrane remodeling events, including the de novo formation of specialized membrane vesicles called autophagosome, which engulf and deliver cargo to the lytic vacuole. In recent years, a few studies have supported the critical role of certain lipids in the autophagic machinery; yet, the exact nature and function of the various lipids involved in autophagosome formation remains largely unexplored in plants. To provide insight into the molecular signature of autophagic membranes in Arabidopsis thaliana, our group has established a method combining purification of autophagic structures with proteomic and lipidomic analysis. This work has enabled us to reveal the singularity of the lipid composition of autophagosomes compared to other membrane compartments, and to identify candidate lipid species currently undergoing in-depth functional analysis to determine their role in membrane remodeling events taking place during autophagy.< Réduire
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Importé de halUnités de recherche