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Human Type-I Interferon Omega Holds Potent Antiviral Properties and Promotes Cytolytic CD8 T Cell Responses.

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorNGUYEN, Hoang Oanh
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorPINSON, Patricia Recordon
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorANDREOLA, Marie-Line
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPAPAGNO, Laura
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorAPPAY, Victor
dc.date.accessioned2025-07-17T10:33:38Z
dc.date.available2025-07-17T10:33:38Z
dc.date.issued2025-07-01
dc.identifier.issn1521-4141en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207347
dc.description.abstractEnThe type-I interferon family is well known for its critical role in innate immunity. It comprises several members, among which IFN-α and IFN-β are the most extensively studied, with important antiviral and immune-modulatory functions. Recent findings linking autoantibodies against type-I interferons to severe COVID-19 suggest a potential role for IFN-ω in combating SARS-CoV-2 infection. However, little is known about human IFN-ω, as most research on this interferon has been conducted in feline models. Here, we demonstrate that human IFN-ω is secreted at levels comparable to those of IFN-α or IFN-β upon stimulation with inflammatory agonists and triggers a robust antiviral response, inhibiting SARS-CoV-2 infection in vitro. Moreover, IFN-ω enhances the effector functions of antigen-specific CD8 T cells primed de novo from healthy donor cells, highlighting its capacity to promote strong cellular immunity. Our results position IFN-ω as a key member of the type-I interferon family, with promising potential for therapeutic and vaccine applications.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enSARS-CoV-2
dc.subject.enInterferon Type I
dc.subject.enCD8-Positive T-Lymphocytes
dc.subject.enAntiviral Agents
dc.subject.enCOVID-19
dc.subject.enInterferon-alpha
dc.title.enHuman Type-I Interferon Omega Holds Potent Antiviral Properties and Promotes Cytolytic CD8 T Cell Responses.
dc.title.alternativeEur J Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/eji.70003en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed40654265en_US
bordeaux.journalEuropean Journal of Immunologyen_US
bordeaux.pagee70003en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue7en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05167378
hal.version1
hal.date.transferred2025-07-17T10:33:40Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Immunology&rft.date=2025-07-01&rft.volume=55&rft.issue=7&rft.spage=e70003&rft.epage=e70003&rft.eissn=1521-4141&rft.issn=1521-4141&rft.au=NGUYEN,%20Hoang%20Oanh&PINSON,%20Patricia%20Recordon&ANDREOLA,%20Marie-Line&PAPAGNO,%20Laura&APPAY,%20Victor&rft.genre=article


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