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CXCL10-dependent epithelial-vascular cross-talk for endothelial activation following SARS-CoV-2 infection.

dc.rights.licenseopenen_US
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorLAURA, Chaillot
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorMARIE-LISE, Blondot
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorPATRICIA, Recordon-Pinson
dc.contributor.authorISABELLE, Pellegrin
dc.contributor.authorANDREA, Boizard-Moracchini
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorMYROSLAVA, Sliusar
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorTEO, Leboucq
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorNADEGE, Pujol
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorMARIE-LINE, Andreola
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFABRICE, Bonnet
hal.structure.identifierInstitut d'Optique Graduate School [IOGS]
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorGAELLE, Recher
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorLAETITIA, Andrique
hal.structure.identifierInstitut d'Optique Graduate School [IOGS]
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorPIERRE, Nassoy
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorTHOMAS, Mathivet
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorANDREAS, Bikfalvi
dc.date.accessioned2025-07-17T10:20:26Z
dc.date.available2025-07-17T10:20:26Z
dc.date.issued2025-07-01
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207344
dc.description.abstractEnThe blood vessel network is heavily impacted by SARS-CoV-2 infection. How SARS-CoV-2 contributes to vascular inflammation and whether epithelio-endothelial cross-talk is involved remain unclear. We investigated in detail the interaction between SARS-CoV-2 and the vasculature using 2D and 3D vesseloid in vitro models. We first assessed whether SARS-CoV-2 is able to directly infect endothelial cells. In the absence of ACE2 in endothelial cells, no productive infection was detected. Low uptake of viral particles by ACE2-overexpressing endothelial cells was observed without efficient viral production. Thus, the indirect effect of SARS-CoV-2 infection may involve epithelio-endothelial cell cross-talk. After infection of the epithelial cells, a significant inflammatory response was detected in the endothelial cells. CXCL10 was the most highly expressed proinflammatory cytokine involved in this intercellular communication, and its function was subsequently explored. Finally, the clinical relevance of our findings was confirmed in two patient cohorts.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHumans
dc.subject.enCOVID-19
dc.subject.enChemokine CXCL10
dc.subject.enSARS-CoV-2
dc.subject.enEndothelial Cells
dc.subject.enCell Communication
dc.subject.enAngiotensin-Converting Enzyme 2
dc.subject.enEpithelial Cells
dc.subject.enHuman Umbilical Vein Endothelial Cells
dc.subject.enEndothelium
dc.subject.enVascular
dc.title.enCXCL10-dependent epithelial-vascular cross-talk for endothelial activation following SARS-CoV-2 infection.
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-025-08329-zen_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed40593263en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page21129en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue1en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05167324
hal.version1
hal.date.transferred2025-07-17T10:20:31Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2025-07-01&rft.volume=15&rft.issue=1&rft.spage=21129&rft.epage=21129&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=LAURA,%20Chaillot&MARIE-LISE,%20Blondot&PATRICIA,%20Recordon-Pinson&ISABELLE,%20Pellegrin&ANDREA,%20Boizard-Moracchini&rft.genre=article


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