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Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MORTESSAGNE, Pierre | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CARTIER, Estelle | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BALIA, Maddalena | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | FÈVRE, Murielle | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CORAILLER, Fiona | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | HERRY, Cyril | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | ABROUS, Djoher Nora | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BATTEFELD, Arne | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | PACARY, Emilie | |
| dc.date.accessioned | 2025-04-30T08:13:26Z | |
| dc.date.available | 2025-04-30T08:13:26Z | |
| dc.date.issued | 2024-02-29 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206495 | |
| dc.description.abstractEn | The dentate gyrus (DG) of the hippocampus is a mosaic of dentate granule neurons (DGNs) accumulated throughout life. While many studies focused on the morpho-functional properties of adult-born DGNs, much less is known about DGNs generated during development, and in particular those born during embryogenesis. One of the main reasons for this gap is the lack of methods available to specifically label and manipulate embryonically-born DGNs. Here, we have assessed the relevance of the PenkCre mouse line as a genetic model to target this embryonically-born population. In young animals, PenkCre expression allows to tag neurons in the DG with positional, morphological and electrophysiological properties characteristic of DGNs born during the embryonic period. In addition, PenkCre+ cells in the DG are distributed in both blades along the entire septo-temporal axis. This model thus offers new possibilities to explore the functions of this underexplored population of embryonically-born DGNs. © The Author(s) 2024. | |
| dc.description.sponsorship | Développement et fonction des nouveaux neurones dans l'hippocampe adulte: exploration du rôle clé joué par Rnd2 - ANR-19-CE16-0014 | en_US |
| dc.description.sponsorship | Rôle de l'organisation à l'échelle nanométrique des récepteurs NMDA dans le développement normal du cerveau et les troubles GRIN. - ANR-22-CE16-0026 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience | en_US |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004 | en_US |
| dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Animals | |
| dc.subject.en | Dentate Gyrus / physiology | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Mice | |
| dc.subject.en | Neurogenesis / physiology | |
| dc.subject.en | Neurons / physiology | |
| dc.title.en | Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line | |
| dc.title.alternative | Sci Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41598-024-55299-9 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38424161 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 5022 | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Neurogénèse et physiopathologie | en_US |
| bordeaux.team | Circuits neuronaux des apprentissages associatifs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2024-02-29&rft.volume=14&rft.issue=1&rft.spage=5022&rft.epage=5022&rft.au=MORTESSAGNE,%20Pierre&CARTIER,%20Estelle&BALIA,%20Maddalena&F%C3%88VRE,%20Murielle&CORAILLER,%20Fiona&rft.genre=article |