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Gamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish

dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
dc.contributor.authorGUIRANDY, Noemie
hal.structure.identifierLaboratoire d'écologie et d'écotoxicologie des radionucléides [IRSN/PSE-ENV/SERPEN/LECO]
dc.contributor.authorSIMON, Olivier
hal.structure.identifierMARine Biodiversity Exploitation and Conservation - MARBEC [UMR MARBEC]
dc.contributor.authorGEFFROY, Benjamin
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDAFFE, Guillemine
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDARAMY, Flore
hal.structure.identifierMARine Biodiversity Exploitation and Conservation - MARBEC [UMR MARBEC]
dc.contributor.authorHOUDELET, Camille
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
dc.date.accessioned2025-03-31T08:40:51Z
dc.date.available2025-03-31T08:40:51Z
dc.date.issued2024-01
dc.identifier.issn0147-6513en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205804
dc.description.abstractEnSex ratio variation is a key topic in ecology, because of its direct effects on population dynamics and thus, on animal conservation strategies. Among factors affecting sex ratio, types of sex determination systems have a central role, since some species could have a sex determined by genetic factors, environmental factors or a mix of those two. Yet, most studies on the factors affecting sex determination have focused on temperature or endocrinedisrupting chemicals (EDCs), and much less is known regarding other factors. Exposure to gamma irradiation was found to trigger offspring masculinization in zebrafish. Here we aimed at deciphering the potential mechanisms involved, by focusing on stress (i.e. cortisol) and epigenetic regulation of key genes involved in sex differentiation in fish. Cortisol levels in exposed and control (F0) zebrafish females' gonads were similar. However, irradiation increased the DNA methylation level of foxl2a and cyp19a1a in females of the F0 and F1 generation, respectively, while no effects were detected in testis. Overall, our results suggest that parental exposure could alter offspring sex ratio, at least in part by inducing methylation changes in ovaries.
dc.description.sponsorshipEffets transgénérationnels des polluants chez les poissons: l'épigénétique et son implication en écotoxicologie - ANR-16-CE34-0008en_US
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enSex differentiation
dc.subject.enMethylation
dc.subject.enCortisol
dc.subject.enZebrafish
dc.subject.enIrradiation
dc.subject.enMultigenerational
dc.title.enGamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ecoenv.2023.115790en_US
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologieen_US
dc.subject.halSciences de l'environnement/Biodiversité et Ecologieen_US
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Zoologie des vertébrésen_US
bordeaux.journalEcotoxicology and Environmental Safetyen_US
bordeaux.page115790en_US
bordeaux.volume269en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04761706
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ecotoxicology%20and%20Environmental%20Safety&rft.date=2024-01&rft.volume=269&rft.spage=115790&rft.epage=115790&rft.eissn=0147-6513&rft.issn=0147-6513&rft.au=GUIRANDY,%20Noemie&SIMON,%20Olivier&GEFFROY,%20Benjamin&DAFFE,%20Guillemine&DARAMY,%20Flore&rft.genre=article


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