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Revolutionizing Dental Implant Research: A Systematic Review on Three-Dimensional In Vitro Models

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSHAYYA, Ghannaa
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBENEDETTI, Clémentine
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCHAGOT, Lise
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSTACHOWICZ, Marie-Laure
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCHASSANDE, Olivier
IDREF: 034414975
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCATROS, Sylvain
dc.date.accessioned2025-03-21T09:52:43Z
dc.date.available2025-03-21T09:52:43Z
dc.date.issued2024-09-16
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205621
dc.description.abstractEnDental implants have been clinically used for almost five decades with high success rates. In vitro research models used in implant dentistry are limited to two-dimensional experiments, which are reproducible and well adapted to evaluate a single parameter but do not reproduce the complexity of clinical settings. On the contrary, the in vivo research models using animals offer similar histological and anatomical features to humans, and tissue healing can be close to a clinical situation, but those models are usually accompanied with ethical concerns, and their outcomes could not be extrapolated to humans because of interspecies variabilities. This makes the development of novel in vitro models that recapitulate physiological events occurring during dental implant placement of particular interest for current research in dentistry. Also, such models could be challenged by setting a pathological environment (peri-implantitis) to better understand the disease and eventually serve as a platform to evaluate novel treatment modalities. The aim of this systematic literature review was to cover all the in vitro three-dimensional (3D) complex models available for research in implant dentistry. To accomplish this, a comprehensive search of the literature present on Scopus and PubMed databases was done using specific keywords, as well as inclusion/exclusion criteria. Out of 1334 articles found, we have finally included 27 articles in this review with publication dates between 2001 and 2022. In those articles, the 3D models were designed to study tissue-implant interface behavior in bone or gingival tissue. The articles focused on simulating implant integration, evaluating the effect of different conditions on implant integration, or developing an infection model for the implant integration process. The methods used involved implant material and cells organized in a specific 3D structure. The 3D models developed were able to simulate the process of dental implant osseo- and soft tissue integration and lead to results comparable with conventional in vitro and in vivo models. A relatively limited number of articles were obtained, which indicates that this is an emerging field, highly dependent on progresses made in biotechnologies and tissue engineering, and that further investigation is needed to enhance these 3D in vitro models. Copyright 2024, Mary Ann Liebert, Inc., publishers.
dc.language.isoENen_US
dc.title.enRevolutionizing Dental Implant Research: A Systematic Review on Three-Dimensional In Vitro Models
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/ten.tec.2023.0380en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalTissue Engineering - Part Cen_US
bordeaux.page368 – 382en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05000228
hal.version1
hal.date.transferred2025-03-21T09:52:45Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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