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Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

dc.rights.licenseopenen_US
dc.contributor.authorZACHOS, Kassandra A
dc.contributor.authorCHOI, Jaehyoung
dc.contributor.authorGODIN, Ophelia
dc.contributor.authorCHERNEGA, Timofei
dc.contributor.authorKWAK, Haejin Angela
dc.contributor.authorJUNG, Jae H
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorAUBIN, Valérie
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorBELZEAUX-R, Raoul
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorETAIN, Bruno
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorLEFRERE A, Antoine
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorROUX, Paul
dc.contributor.authorBARAU, Caroline
dc.contributor.authorRICHARD, Jean Romain
dc.contributor.authorTAMOUZA, Ryad
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorANDREAZZA, Ana C
dc.contributor.authorETAIN, Bruno
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorLLORCA, Pierre-Michel M
dc.contributor.authorBARTEAU, V.
dc.contributor.authorBENSALEM, S.
dc.contributor.authorGODIN, Ophelia
dc.contributor.authorLAOUAMRI, H.
dc.contributor.authorSOURYIS, K.
dc.contributor.authorHOTIER, S.
dc.contributor.authorPELLETIER, A.
dc.contributor.authorHERGETA, F.
dc.contributor.authorPETRUCCI, J.
dc.contributor.authorWILLAUME, L.
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorETAIN, Bruno
dc.contributor.authorHENNION, V.
dc.contributor.authorMARLINGE, E.
dc.contributor.authorMEHEUST, J.
dc.contributor.authorRICHARD, A.
dc.contributor.authorCARMINATI, M.
dc.contributor.authorFRANCISQUE, H.
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorMAZER, N.
dc.contributor.authorPORTALIER, C.
dc.contributor.authorSCOGNAMIGLIO, C.
dc.contributor.authorBING, A.
dc.contributor.authorLAURENT, P.
dc.contributor.authorGARD, S.
dc.contributor.authorM'BAILARA, K.
dc.contributor.authorELKAEL, C.
dc.contributor.authorHOORELBEKE, F.
dc.contributor.authorMINOIS, I.
dc.contributor.authorSPORTICH, J.
dc.contributor.authorDA ROS, N.
dc.contributor.authorBOUKHOBZA, L.
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorDENAT, S.
dc.contributor.authorDEFFINIS, B.
dc.contributor.authorDUCASSE, D.
dc.contributor.authorGACHET, M.
dc.contributor.authorLENGVENYTÉ, A.
dc.contributor.authorMOLIÈRE, F.
dc.contributor.authorNASS, L.
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorTARQUINI, G.
dc.contributor.authorLEFRERE, Antoine
dc.contributor.authorMOREAU, E.
dc.contributor.authorPASTOL, J.
dc.contributor.authorGROPPI, F.
dc.contributor.authorPOLOMENI, H.
dc.contributor.authorBAUBERG, J
dc.contributor.authorLESCALIER, L.
dc.contributor.authorMURACCIOLI, I.
dc.contributor.authorSURAY, A.
dc.contributor.authorCOHEN, R.
dc.contributor.authorKAHN, J.P.
dc.contributor.authorMILAZZO, M.
dc.contributor.authorWAJSBROT-ELGRABLI, O.
dc.contributor.authorBOUGEROL, T.
dc.contributor.authorPOUCHON, A.
dc.contributor.authorBERTRAND, A
dc.contributor.authorFREDEMBACH, B.
dc.contributor.authorSUISSE, A.
dc.contributor.authorDENOUAL, Q
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorGALLIOT, A.M.
dc.contributor.authorBREHON, L.
dc.contributor.authorBONNY, G
dc.contributor.authorDURAND, L
dc.contributor.authorFEUGA, V
dc.contributor.authorKAYSER, N.
dc.contributor.authorROUX, Paul
dc.contributor.authorAUBIN, Valérie
dc.contributor.authorCUSSAC, I.
dc.contributor.authorDUPONT, M A
dc.contributor.authorLOFTUS, J.
dc.contributor.authorMEDECIN, I.
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorMAZER, N.
dc.contributor.authorLAURENT, P.
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorLLORCA, PM
dc.contributor.authorMENNETRIER, M.
dc.contributor.authorBONNET, T.
dc.contributor.authorLACELLE, D.
dc.contributor.authorVAYSSIÉ, M.
dc.contributor.authorBEAL, C.
dc.contributor.authorBLANC, O.
dc.date.accessioned2025-03-17T14:52:30Z
dc.date.available2025-03-17T14:52:30Z
dc.date.issued2024-09
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205519
dc.description.abstractEnThe object of this study is test whether mitochondrial blood-based biomarkers are associated with markers of metabolic syndrome in bipolar disorder, hypothesizing higher lactate but unchanged cell-free circulating mitochondrial DNA levels in bipolar disorder patients with metabolic syndrome. In a cohort study, primary testing from the FondaMental Advanced Centers of Expertise for bipolar disorder (FACE-BD) was conducted, including 837 stable bipolar disorder patients. The I-GIVE validation cohort consists of 237 participants: stable and acute bipolar patients, non-psychiatric controls, and acute schizophrenia patients. Multivariable regression analyses show significant lactate association with triglycerides, fasting glucose and systolic and diastolic blood pressure. Significantly higher levels of lactate were associated with presence of metabolic syndrome after adjusting for potential confounding factors. Mitochondrial-targeted metabolomics identified distinct metabolite profiles in patients with lactate presence and metabolic syndrome, differing from those without lactate changes but with metabolic syndrome. Circulating cell-free mitochondrial DNA was not associated with metabolic syndrome. This thorough analysis mitochondrial biomarkers indicate the associations with lactate and metabolic syndrome, while showing the mitochondrial metabolites can further stratify metabolic profiles in patients with BD. This study is relevant to improve the identification and stratification of bipolar patients with metabolic syndrome and provide potential personalized-therapeutic opportunities.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortesen_US
dc.description.sponsorshipMicroglial activation in Complement C4-stratified schizophrenic patients and in a mouse model of C4 overexpressionen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBipolar disorder
dc.subject.enCirculating cell free mitochondrial DNA
dc.subject.enLactate
dc.subject.enMetabolic syndrome
dc.subject.enMitochondrial blood-based biomarkers
dc.subject.enMitochondrial metabolomics
dc.subject.enMood disorder
dc.title.enMitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psychres.2024.116063en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39003800en_US
bordeaux.journalPsychiatry researchen_US
bordeaux.page116063en_US
bordeaux.volume339en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychiatry%20research&rft.date=2024-09&rft.volume=339&rft.spage=116063&rft.epage=116063&rft.au=ZACHOS,%20Kassandra%20A&CHOI,%20Jaehyoung&GODIN,%20Ophelia&CHERNEGA,%20Timofei&KWAK,%20Haejin%20Angela&rft.genre=article


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