Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LI, Bo | |
| dc.contributor.author | WU, Jun | |
| dc.contributor.author | TANG, Lei | |
| dc.contributor.author | LIAN, Xu | |
| dc.contributor.author | LI, Zhongwen | |
| dc.contributor.author | DUAN, Wenfang | |
| dc.contributor.author | QIN, Tong | |
| dc.contributor.author | ZHAO, Xintong | |
| dc.contributor.author | HU, Yuhua | |
| dc.contributor.author | ZHANG, Chi | |
| dc.contributor.author | LI, Tianlei | |
| dc.contributor.author | HAO, Jie | |
| dc.contributor.author | ZHANG, Wenxuan | |
| dc.contributor.author | ZHANG, Jihong | |
| dc.contributor.author | WU, Song | |
| dc.date.accessioned | 2025-02-11T15:02:14Z | |
| dc.date.available | 2025-02-11T15:02:14Z | |
| dc.date.issued | 2021-12-30 | |
| dc.identifier.issn | 1477-0539 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204797 | |
| dc.description.abstractEn | Seventeen C20-O-alkyl/benzyl oxime derivatives were synthesized by a concise and effective method. Most of these derivatives showed tens to several hundred nanomolar IC50 values against HT-29 colorectal, HGC-27 gastric and MDA-MB-231 breast cancer cells, whose antiproliferative activity is 15–240 fold better than that of salinomycin. The C20-oxime etherified derivatives can coordinate potassium ions, and further adjust the cytosolic Ca2+ concentrations in HT-29 cells. The significant improvement of the potency should be attributed to the better ion binding and transport ability of the modified derivatives. In addition, the C20-O-alkyl/benzyl oxime derivatives showed much better selectivity indexes (SI) than salinomycin, indicating that they present lower neurotoxic risk. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives | |
| dc.title.alternative | Org. Biomol. Chem. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1039/D1OB02292J | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| dc.identifier.pubmed | 35006233 | en_US |
| bordeaux.journal | Organic & Biomolecular Chemistry | en_US |
| bordeaux.page | 870-876 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04941005 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-02-11T15:02:17Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Organic%20&%20Biomolecular%20Chemistry&rft.date=2021-12-30&rft.volume=20&rft.issue=4&rft.spage=870-876&rft.epage=870-876&rft.eissn=1477-0539&rft.issn=1477-0539&rft.au=LI,%20Bo&WU,%20Jun&TANG,%20Lei&LIAN,%20Xu&LI,%20Zhongwen&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||