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The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study

dc.rights.licenseopenen_US
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
hal.structure.identifierService d'endocrinologie diabétologie et nutrition [Rennes]
dc.contributor.authorBONNET, Fabrice
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorBALKAU, Beverley
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorLAMBERT, Oriane
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorDIAWARA, Yakhara
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorCOMBE, Christian
ORCID: 0000-0002-0360-573X
IDREF: 58708871
hal.structure.identifierAdaptation, mesure et évaluation en santé. Approches interdisciplinaires [APEMAC]
hal.structure.identifierService de Néphrologie [CHRU Nancy]
hal.structure.identifierCentre d'investigation clinique [Nancy] [CIC]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
hal.structure.identifierAssociation pour l'Utilisation du Rein Artificiel Région Lyonnaise [AURAL]
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierMécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 [MP3CV]
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorLIABEUF, Sophie
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierHôpital Ambroise Paré [AP-HP]
dc.contributor.authorMASSY, Ziad
hal.structure.identifierGériatrie [AP-HP Ambroise-Paré]
dc.contributor.authorMETZGER, Marie
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, Bénédicte
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorALENCAR DE PINHO, Natalia
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
dc.contributor.authorFOUQUE, Denis
dc.date.accessioned2025-02-10T12:28:31Z
dc.date.available2025-02-10T12:28:31Z
dc.date.issued2024-02-28
dc.identifier.issn1462-8902en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204779
dc.description.abstractEnAim The risk of cardiorenal events remains high among patients with diabetes and chronic kidney disease (CKD), despite the prescription of recommended treatments. We aimed to determine whether the attainment of a combination of nephroprotection targets at baseline (glycated haemoglobin <7.0%, urinary albumin‐creatinine ratio <300 mg/g, blood pressure <130/80 mmHg, renin‐angiotensin system inhibition) was associated with better cardiorenal outcomes and lower mortality. Materials and Methods From the prospective French CKD‐REIN cohort, we studied 1260 patients with diabetes and CKD stages 3‐4 (estimated glomerular filtration rate: 15‐60 ml/min/1.73 m 2 ); 69% were men, and at inclusion, mean ± SD age: 70 ± 10 years; estimated glomerular filtration rate: 33 ± 11 ml/min/1.73 m 2 . The median follow‐up was 4.9 years. Results In adjusted Cox regression models, the attainment of two nephroprotection targets was consistently associated with a lower risk of cardiorenal events [hazard ratio 0.70 (95% confidence interval 0.57‐0.85)], incident kidney failure with replacement therapy [0.58 (0.43‐0.77)], four major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure) [0.75 (0.57‐0.99)] and all‐cause mortality [0.59 (0.42‐0.82)] when compared with the attainment of zero or one target. For patients with a urinary albumin‐creatinine ratio ≥300 mg/g, those who attained at least two targets had lower hazard ratios for cardiorenal events [0.61 (0.39‐0.96)], four major adverse cardiovascular events [0.53 (0.28‐0.98)] and all‐cause mortality [0.35 (0.17‐0.70)] compared with those who failed to attain any targets. Conclusions These findings suggest that the attainment of a combination of nephroprotection targets is associated with better cardiorenal outcomes and a lower mortality rate in people with diabetic kidney disease.
dc.language.isoENen_US
dc.subject.encardiovascular disease
dc.subject.endiabetic nephropathy
dc.subject.enpharmaco-epidemiology
dc.subject.entype 2 diabetes
dc.title.enThe number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/dom.15507en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalDiabetes, Obesity and Metabolismen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.import.sourcehal
hal.identifierhal-04484106
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Diabetes,%20Obesity%20and%20Metabolism&amp;rft.date=2024-02-28&amp;rft.eissn=1462-8902&amp;rft.issn=1462-8902&amp;rft.au=BONNET,%20Fabrice&amp;BALKAU,%20Beverley&amp;LAMBERT,%20Oriane&amp;DIAWARA,%20Yakhara&amp;COMBE,%20Christian&amp;rft.genre=article


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