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Energy metabolism rewiring following acute UVB irradiation is largely dependent on nuclear DNA damage.

dc.rights.licenseopenen_US
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorDOUSSET, Lea
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorMAHFOUF, Walid
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorYOUNES, Hadi
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorFATROUNI, Hala
IDREF: 256973717
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorFAUCHEUX, Corinne
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorMUZOTTE, Elodie
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorKHALIFE, Ferial
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorROSSIGNOL, Rodrigue
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorMOISAN, Francois
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorCARIO, Muriel
hal.structure.identifierPlateforme Protéome [Bordeaux]
dc.contributor.authorCLAVEROL, Stéphane
dc.contributor.authorFAVOT-LAFORGE, Laure
dc.contributor.authorNIEMINEN, Anni I
dc.contributor.authorVAINIO, Seppo
dc.contributor.authorALI, Nsrein
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorREZVANI, Hamid Reza
dc.date.accessioned2025-01-28T11:04:02Z
dc.date.available2025-01-28T11:04:02Z
dc.date.issued2024-12-10
dc.identifier.issn1873-4596en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204620
dc.description.abstractEnSolar ultraviolet B (UVB) radiation-induced DNA damage is a well-known initiator of skin carcinomas. The UVB-induced DNA damage response (DDR) involves series of signaling cascades that are activated to maintain cell integrity. Among the different biological processes, little is known about the role of energy metabolism in the DDR. We sought to determine whether UVB-induced nuclear and/or mitochondrial cyclobutane pyrimidine dimers (CPDs) alter cellular energy metabolism. To gain insight into this question, we took advantage of keratinocytes expressing nuclear or mitochondrial CPD photolyase. Applying a quantitative proteomic approach and targeted metabolomics, we observed biphasic alterations in multiple metabolic pathways and in the abundance of various metabolites, largely influenced by the presence of genomic CPDs. The heightened oxygen consumption rate post-irradiation, along with mitochondrial structural rearrangements, was found to be dependent on both mitochondrial and nuclear CPDs. Understanding the influence of nuclear and mitochondrial DNA damage on keratinocyte responses to UVB irradiation deepens current knowledge regarding skin cancer prevention, initiation, and therapy.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enEnergy metabolism rewiring following acute UVB irradiation is largely dependent on nuclear DNA damage.
dc.title.alternativeFree Radic Biol Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.freeradbiomed.2024.12.030en_US
dc.subject.halSciences du Vivant [q-bio]/Génétiqueen_US
dc.identifier.pubmed39667588en_US
bordeaux.journalFree Radical Biology and Medicineen_US
bordeaux.page459-471en_US
bordeaux.volume227en_US
bordeaux.hal.laboratoriesMaladies Rares : Génétique et Métabolisme (MRGM) - UMR 1211en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Free%20Radical%20Biology%20and%20Medicine&rft.date=2024-12-10&rft.volume=227&rft.spage=459-471&rft.epage=459-471&rft.eissn=1873-4596&rft.issn=1873-4596&rft.au=DOUSSET,%20Lea&MAHFOUF,%20Walid&YOUNES,%20Hadi&FATROUNI,%20Hala&FAUCHEUX,%20Corinne&rft.genre=article


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