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Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome.

dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social [LIP-PC2S]
dc.contributor.authorPELLISSIER, Sonia
hal.structure.identifierLaboratoire de psychologie [LabPsy]
dc.contributor.authorDANTZER, Cecile
ORCID: 0000-0001-9109-5444
IDREF: 071348050
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
hal.structure.identifierUniversité Clermont Auvergne [UCA]
hal.structure.identifierLaboratoire de Psychologie Sociale et Cognitive [LAPSCO]
dc.contributor.authorMONDILLON, Laurie
hal.structure.identifierInstitut de Biologie et de Pathologie [CHU Grenoble] [IBP]
dc.contributor.authorTROCME, Candice
hal.structure.identifierInstitut de Biologie et de Pathologie [CHU Grenoble] [IBP]
dc.contributor.authorGAUCHEZ, Anne Sophie
hal.structure.identifierInstitut de Biologie et de Pathologie [CHU Grenoble] [IBP]
dc.contributor.authorDUCROS, Veronique
hal.structure.identifierDépartement d'hépato-gastroentérologie
hal.structure.identifierCentre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
dc.contributor.authorMATHIEU, Nicolas
hal.structure.identifierCentre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
hal.structure.identifierORSTOM
hal.structure.identifierUniversité Grenoble Alpes [UGA]
hal.structure.identifierTranslational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 [TIMC]
hal.structure.identifierTranslational microbial Evolution and Engineering [TIMC-TrEE]
dc.contributor.authorTOUSSAINT, Bertrand
hal.structure.identifierUniversité Clermont Auvergne [UCA]
hal.structure.identifierLaboratoire de Psychologie Sociale et Cognitive [LAPSCO]
dc.contributor.authorFOURNIER, Alicia
hal.structure.identifierCentre de Recherches du Service de Santé des Armées [CRSSA]
hal.structure.identifierÉcole du Val de Grâce [EVDG]
hal.structure.identifierDépartement des Facteurs Humains
hal.structure.identifierInstitut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] [IRBA]
dc.contributor.authorCANINI, Frederic
hal.structure.identifierDépartement d'hépato-gastroentérologie
hal.structure.identifierDépartement de Gastroentérologie et hépatologie
hal.structure.identifierCentre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorBONAZ, Bruno
dc.date.accessioned2025-01-16T14:54:39Z
dc.date.available2025-01-16T14:54:39Z
dc.date.issued2014-01-01
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204326
dc.description.abstractEnCrohn's disease (CD) and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where vagus nerve is an important component. The aim of this work was to study the association between vagal tone and markers of stress and inflammation in patients with CD or IBS compared to healthy subjects (controls). The study was performed in 73 subjects (26 controls, 21 CD in remission and 26 IBS patients). The day prior to the experiment, salivary cortisol was measured at 8:00 AM and 10:00 PM. The day of the experiment, subjects completed questionnaires for anxiety (STAI) and depressive symptoms (CES-D). After 30 min of rest, ECG was recorded for heart rate variability (HRV) analysis. Plasma cortisol, epinephrine, norepinephrine, TNF-alpha and IL-6 were measured in blood samples taken at the end of ECG recording. Compared with controls, CD and IBS patients had higher scores of state-anxiety and depressive symptomatology. A subgroup classification based on HRV-normalized high frequency band (HFnu) as a marker of vagal tone, showed that control subjects with high vagal tone had significantly lower evening salivary cortisol levels than subjects with low vagal tone. Such an effect was not observed in CD and IBS patients. Moreover, an inverse association (r =  -0.48; p<0.05) was observed between the vagal tone and TNF-alpha level in CD patients exclusively. In contrast, in IBS patients, vagal tone was inversely correlated with plasma epinephrine (r =  -0.39; p<0.05). No relationship was observed between vagal tone and IL-6, norepinephrine or negative affects (anxiety and depressive symptomatology) in any group. In conclusion, these data argue for an imbalance between the hypothalamus-pituitary-adrenal axis and the vagal tone in CD and IBS patients. Furthermore, they highlight the specific homeostatic link between vagal tone and TNF-alpha in CD and epinephrine in IBS and argue for the relevance of vagus nerve reinforcement interventions in those diseases.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enRelationship between Vagal Tone
dc.subject.enCortisol
dc.subject.enTNF-Alpha
dc.subject.enEpinephrine and Negative Affects in Crohn’s Disease and Irritable Bowel Syndrome
dc.title.enRelationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome.
dc.title.alternativePLoS Oneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0105328en_US
dc.subject.halSciences de l'Homme et Société/Psychologieen_US
dc.identifier.pubmed25207649en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee105328en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesLaboratoire de psychologie (LabPsy) - UR 4139en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAssociation Francois Aupetiten_US
bordeaux.identifier.funderIDSociété Nationale Française de Gastro-Entérologieen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=PLoS%20ONE&amp;rft.date=2014-01-01&amp;rft.volume=9&amp;rft.issue=9&amp;rft.spage=e105328&amp;rft.epage=e105328&amp;rft.eissn=1932-6203&amp;rft.issn=1932-6203&amp;rft.au=PELLISSIER,%20Sonia&amp;DANTZER,%20Cecile&amp;MONDILLON,%20Laurie&amp;TROCME,%20Candice&amp;GAUCHEZ,%20Anne%20Sophie&amp;rft.genre=article


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