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Frailty and pre-frailty phenotypes increase the odds of abnormal cognitive impairment screens in people living with HIV

dc.rights.licenseopenen_US
dc.contributor.authorMAKINSON, Alain
dc.contributor.authorALLAVENA, Clotilde
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorABULIZI, Xian
dc.contributor.authorSLAMA, Laurence
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorCASES, Antoine
dc.contributor.authorTROUILLET, Marion Bourgey
dc.contributor.authorBLONDEL, Guillaume Martin
dc.contributor.authorGENY, Christian
dc.contributor.authorLECLERCQ, Pascale
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorCAZANAVE, Charles
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorNAQVI, Alissa
dc.contributor.authorDAVID-CHEVALLIER, Perla
dc.contributor.authorARVIEUX, Cédric
dc.contributor.authorKATLAMA, Christine
hal.structure.identifierPathogenesis and Control of Chronic and Emerging Infections [PCCEI]
dc.contributor.authorCABIE, André
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorANDRIANTSOANIRINA, Valérie
dc.contributor.authorBLAIN, Hubert
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorMEYER, Laurence
dc.date.accessioned2025-01-14T07:55:08Z
dc.date.available2025-01-14T07:55:08Z
dc.date.issued2023-08-03
dc.identifier.issn0269-9370en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204249
dc.description.abstractEnObjective: Evaluate whether pre-frail and frail PLWH have a higher risk of cognitive impairment on screens. Methods: Analysis of PLWH aged 70 or older included in the ANRS EP66 SEPTAVIH cohort, on antiretroviral therapy for at least 12 months and with a MoCA test at enrolment. Adjusted risk of a Montreal Cognitive Assessment (MoCA) 30.2), and 41.3% were college graduates; 27.3% had a history of clinical AIDS. 294 (58.5%) PLWH had a MoCA score <26; 182 (36%) a MoCA score ≤ 23. Frailty, pre-frailty, and robustness were found in 13.1%, 63.6% and 23.3% participants, respectively. PLWH with a MoCA < 26 had a significantly higher risk of being frail/prefrail, this before (OR = 2.31 [95% CI: 1.50, 3.57]), and after adjustment for confounders (OR = 1.80, [1.07–3.01]). The risk of being frail/prefrail in patients with a MoCA ≤ 23 was higher (adjusted OR = 2.75, [95%CI: 1.46–5.16]). Other factors independently associated with a MoCA < 26 were older age, birth outside of France, and a lower education level and being diabetic. Conclusions: Abnormal MoCA screens were frequent in our cohort of PLWH aged 70 or older with controlled HIV disease. Cognitive impairment should be systematically screened in frail/prefrail PLWH. Frailty/pre-frailty, diabetes and social factors, but not HIV-related factors, are important determinants of cognitive function in PLWH with controlled disease.
dc.language.isoENen_US
dc.title.enFrailty and pre-frailty phenotypes increase the odds of abnormal cognitive impairment screens in people living with HIV
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/QAD.0000000000003681en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieusesen_US
dc.identifier.pubmed37534690en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04240927
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&amp;rft.date=2023-08-03&amp;rft.eissn=0269-9370&amp;rft.issn=0269-9370&amp;rft.au=MAKINSON,%20Alain&amp;ALLAVENA,%20Clotilde&amp;ABULIZI,%20Xian&amp;SLAMA,%20Laurence&amp;CASES,%20Antoine&amp;rft.genre=article


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