Similar Kinetics of Pulmonary SARS-CoV-2 Load in Intensive Care Unit Patients with COVID-19 Pneumonia with or Without Autoantibodies Neutralizing Type I Interferons.
| dc.rights.license | open | en_US |
| dc.contributor.author | LE STANG, Valentine | |
| dc.contributor.author | BASTARD, Paul | |
| dc.contributor.author | LANGOUET, Elise | |
| dc.contributor.author | PINETON DE CHAMBRUN, Marc | |
| dc.contributor.author | CHOMMELOUX, Juliette | |
| dc.contributor.author | GERVAIS, Adrian | |
| dc.contributor.author | BIZIEN, Lucy | |
| dc.contributor.author | PUEL, Anne | |
| dc.contributor.author | COBAT, Aurélie | |
| dc.contributor.author | MAYAUX, Julien | |
| dc.contributor.author | DEMOULE, Alexandre | |
| dc.contributor.author | CASANOVA, Jean-Laurent | |
| dc.contributor.author | BOUTOLLEAU, David | |
| dc.contributor.author | COMBES, Alain | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BURREL, Sonia | |
| dc.contributor.author | LUYT, Charles-Edouard | |
| dc.date.accessioned | 2025-01-07T14:19:47Z | |
| dc.date.available | 2025-01-07T14:19:47Z | |
| dc.date.issued | 2024-11-20 | |
| dc.identifier.issn | 1573-2592 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204169 | |
| dc.description.abstractEn | The pathogenesis of life-threatening coronavirus disease 2019 (COVID-19) pneumonia in ICU patients can involve pre-existing auto-antibodies (auto-Abs) neutralizing type I interferons (IFNs). The impact of these auto-Abs on SARS-CoV-2 clearance in the lower respiratory tract (LRT) is unclear. We performed a retrospective study in 99 ICU patients with COVID-19 pneumonia between March and May 2020. LRT SARS-CoV-2 load (intensity and duration) was analyzed according to the presence or not of circulating auto-Abs neutralizing type I IFNs. Among the 99 included patients, 38 (38%) were positive for auto-Abs neutralizing type I IFNs, with 5 (5%) harboring auto-Abs neutralizing IFN-α2 at any concentration, while 33 (33%) had auto-Abs neutralizing only IFN-ω at the lower concentration. SARS-CoV-2 load in the LRT and duration of viral shedding, were similar in patients with or without auto-Abs neutralizing type I IFNs. Patients with auto-Abs had the same mortality than those without auto-Abs, despite greater occurrence of renal failure and ECMO support, and longer duration of mechanical ventilation and ICU stay. In summary, 5% of patients with critical COVID-19 pneumonia carried auto-Abs neutralizing IFN-α2, while about 1/3 harbored auto-Abs neutralizing low concentrations of IFN-ω. The detection of either type of auto-Abs did not impact LRT viral clearance and mortality, although it was associated with greater morbidity and a longer hospitalization. These findings suggest that similar albeit hitherto unknown mechanisms of disease drive critical COVID-19 pneumonia in patients without auto-Abs against type I IFNs. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Humans | |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Male | |
| dc.subject.en | SARS-CoV-2 | |
| dc.subject.en | Female | |
| dc.subject.en | Interferon Type I | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Autoantibodies | |
| dc.subject.en | Retrospective Studies | |
| dc.subject.en | Intensive Care Units | |
| dc.subject.en | Antibodies | |
| dc.subject.en | Neutralizing | |
| dc.subject.en | Aged | |
| dc.subject.en | Viral Load | |
| dc.subject.en | Adult | |
| dc.subject.en | Kinetics | |
| dc.title.en | Similar Kinetics of Pulmonary SARS-CoV-2 Load in Intensive Care Unit Patients with COVID-19 Pneumonia with or Without Autoantibodies Neutralizing Type I Interferons. | |
| dc.title.alternative | J Clin Immunol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s10875-024-01839-x | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 39565497 | en_US |
| bordeaux.journal | Journal of Clinical Immunology | en_US |
| bordeaux.page | 45 | en_US |
| bordeaux.volume | 45 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04871072 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-01-07T14:19:49Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Immunology&rft.date=2024-11-20&rft.volume=45&rft.issue=1&rft.spage=45&rft.epage=45&rft.eissn=1573-2592&rft.issn=1573-2592&rft.au=LE%20STANG,%20Valentine&BASTARD,%20Paul&LANGOUET,%20Elise&PINETON%20DE%20CHAMBRUN,%20Marc&CHOMMELOUX,%20Juliette&rft.genre=article |
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