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Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGOUNOU, Celine
dc.contributor.authorROUYER, Lucile
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorSIEGFRIED, Geraldine
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorHARTE, Etienne
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBOUVET, Flora
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorD'AGATA, Lena
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDARBO, Elodie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLEFEUVRE, Martin
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDERIEPPE, M
dc.contributor.authorBOUTON, Lea
dc.contributor.authorMELANE, Mailys
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCHAPEAU, Dorian
dc.contributor.authorMARTINEAU, Julie
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorPROUZET-MAULEON, Valerie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorTAN, Sisareuth
dc.contributor.authorSOULEYREAU, Wilfried
dc.contributor.authorSALTEL, Frederic
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorARGOUL, Francoise
dc.contributor.authorKHATIB, Abdel‐majid
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBRISSON, Alain
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorIGGO, Richard
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBOUTER, Anthony
dc.date.accessioned2024-12-19T09:54:28Z
dc.date.available2024-12-19T09:54:28Z
dc.date.issued2023-12-13
dc.identifier.issn1420-682Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204003
dc.description.abstractEnCancer cells are exposed to major compressive and shearing forces during invasion and metastasis, leading to extensive plasma membrane damage. To survive this mechanical stress, they need to repair membrane injury efficiently. Targeting the membrane repair machinery is thus potentially a new way to prevent invasion and metastasis. We show here that annexin-A2 (ANXA2) is required for membrane repair in invasive breast and pancreatic cancer cells. Mechanistically, we show by fluorescence and electron microscopy that cells fail to reseal shear-stress damaged membrane when ANXA2 is silenced or the protein is inhibited with neutralizing antibody. Silencing of ANXA2 has no effect on proliferation in vitro, and may even accelerate migration in wound healing assays, but reduces tumor cell dissemination in both mice and zebrafish. We expect that inhibiting membrane repair will be particularly effective in aggressive, poor prognosis tumors because they rely on the membrane repair machinery to survive membrane damage during tumor invasion and metastasis. This could be achieved either with anti-ANXA2 antibodies, which have been shown to inhibit metastasis of breast and pancreatic cancer cells, or with small molecule drugs.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAnnexins
dc.subject.enInvasion
dc.subject.enMetastasis
dc.subject.enTumor progression
dc.subject.enS100 proteins
dc.subject.enMDA-MB-231
dc.subject.enAsPC-1
dc.title.enInhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00018-023-05049-3en_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaireen_US
bordeaux.journalCellular and Molecular Life Sciencesen_US
bordeaux.page7en_US
bordeaux.volume81en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04687405
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cellular%20and%20Molecular%20Life%20Sciences&rft.date=2023-12-13&rft.volume=81&rft.issue=1&rft.spage=7&rft.epage=7&rft.eissn=1420-682X&rft.issn=1420-682X&rft.au=GOUNOU,%20Celine&ROUYER,%20Lucile&SIEGFRIED,%20Geraldine&HARTE,%20Etienne&BOUVET,%20Flora&rft.genre=article


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