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Real-time cognitive performance and positive symptom expression in schizophrenia.

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDUPUY, Maud
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorABDALLAH, Majd
hal.structure.identifierÉcole Pratique des Hautes Études [EPHE]
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSWENDSEN, Joel
hal.structure.identifierHandicap et système nerveux :Action, communication, interaction: rétablissement de la fonction et de la participation [Bordeaux] [EA4136]
hal.structure.identifierHandicap Activité Cognition Santé [Bordeaux] [HACS]
dc.contributor.authorN'KAOUA, Bernard
hal.structure.identifierÉcole Pratique des Hautes Études [EPHE]
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCHANRAUD, Sandra
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSCHWEITZER, Pierre
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorFATSEAS, Melina
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorSERRE, Fushia
hal.structure.identifierÉcole Pratique des Hautes Études [EPHE]
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBARSE, Elodie
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
dc.contributor.authorAURIACOMBE, Marc
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
dc.contributor.authorMISDRAHI, David
dc.date.accessioned2024-12-17T09:39:04Z
dc.date.available2024-12-17T09:39:04Z
dc.date.issued2021-07-21
dc.identifier.issn1433-8491en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203973
dc.description.abstractEnDeficits in cognitive functions are frequent in schizophrenia and are often conceptualized as stable characteristics of this disorder. However, cognitive capacities may fluctuate over the course of a day and it is unknown if such variation may be linked to the dynamic expression of psychotic symptoms. This investigation used Ecological Momentary Assessment (EMA) to provide mobile tests of cognitive functions and positive symptoms in real time. Thirty-three individuals with schizophrenia completed five EMA assessments per day for a one-week period that included real-time assessments of cognitive performance and psychotic symptoms. A subsample of patients and 31 healthy controls also completed a functional MRI examination. Relative to each individual's average score, moments of worsened cognitive performance on the mobile tests were associated with an increased probability of positive symptom occurrence over subsequent hours of the day (coef = 0.06, p < 0.05), adjusting for the presence of psychotic symptoms at the moment of mobile test administration. These prospective associations varied as a function of graph theory indices in MRI analyses. These findings demonstrate that cognitive performance is prospectively linked to psychotic symptom expression in daily life, and that underlying brain markers may be observed in the Executive Control Network. While the potential causal nature of this association remains to be investigated, our results offer promising prospects for a better understanding of the underlying mechanisms of symptom expression in schizophrenia.
dc.description.sponsorshipDéficits cognitifs dans la dépendance aux drogues et troubles mentaux comorbides - ANR-12-BSH2-0012en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enSchizophrenia
dc.subject.enEcological Momentary Assessment
dc.subject.enCognitive functions
dc.subject.enPositive symptoms
dc.subject.enMagnetic resonance imaging
dc.subject.enGraph theory
dc.title.enReal-time cognitive performance and positive symptom expression in schizophrenia.
dc.title.alternativeEur Arch Psychiatry Clin Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00406-021-01296-2en_US
dc.subject.halSciences de l'Homme et Société/Psychologieen_US
dc.identifier.pubmed34287696en_US
bordeaux.journalEuropean Archives of Psychiatry and Clinical Neuroscienceen_US
bordeaux.page415-425en_US
bordeaux.volume272en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=European%20Archives%20of%20Psychiatry%20and%20Clinical%20Neuroscience&amp;rft.date=2021-07-21&amp;rft.volume=272&amp;rft.issue=3&amp;rft.spage=415-425&amp;rft.epage=415-425&amp;rft.eissn=1433-8491&amp;rft.issn=1433-8491&amp;rft.au=DUPUY,%20Maud&amp;ABDALLAH,%20Majd&amp;SWENDSEN,%20Joel&amp;N'KAOUA,%20Bernard&amp;CHANRAUD,%20Sandra&amp;rft.genre=article


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