| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | ALLMANN, Stefan | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | WARGNIES, Marion | |
| hal.structure.identifier | Toulouse Biotechnology Institute [TBI] | |
| hal.structure.identifier | MetaboHUB-MetaToul | |
| hal.structure.identifier | STROMALab | |
| dc.contributor.author | CAHOREAU, Edern | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BIRAN, Marc | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PLAZOLLES, Nicolas | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | MORAND, Pauline | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PINEDA, Erika | |
| hal.structure.identifier | Toulouse Biotechnology Institute [TBI] | |
| hal.structure.identifier | MetaboHUB-MetaToul | |
| hal.structure.identifier | STROMALab | |
| dc.contributor.author | KULYK, Hanna | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ASENCIO, Corinne | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | VILLAFRAZ, Oriana | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | RIVIÈRE, Loïc | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | TETAUD, Emmanuel | |
| hal.structure.identifier | Biologie cellulaire des Trypanosomes - Trypanosome Cell Biology | |
| dc.contributor.author | ROTUREAU, Brice | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | MOURIER, Arnaud | |
| hal.structure.identifier | Toulouse Biotechnology Institute [TBI] | |
| hal.structure.identifier | STROMALab | |
| hal.structure.identifier | MetaboHUB-MetaToul | |
| dc.contributor.author | PORTAIS, Jean-Charles | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BRINGAUD, Frédéric | |
| dc.date.accessioned | 2024-12-13T09:26:28Z | |
| dc.date.available | 2024-12-13T09:26:28Z | |
| dc.date.created | 2019-01-01 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203916 | |
| dc.description.abstractEn | SUMMARY Microorganisms must make the right choice for nutrient consumption to adapt to their changing environment. As a consequence, bacteria and yeasts have developed regulatory mechanisms involving nutrient sensing and signaling, allowing to redirect cell metabolism to maximize the consumption of an energy-efficient carbon source. Here, we report a new mechanism, named ``metabolic contest'', for regulating the use of carbon sources without nutrient sensing and signaling. In contrast to most microorganisms, trypanosomes show a glycerol-to-glucose preference that depends on the combination of three conditions: ( i ) the sequestration of both metabolic pathways in the same subcellular compartment, here in the peroxisomal-like organelles named glycosomes; ( ii ) the competition for the same substrate, here ATP, with the first enzymatic step of the glycerol and glucose metabolic pathways being both ATP-dependent (glycerol kinase and hexokinase, respectively) and ( iii ) an unbalanced activity between the competing enzymes, here the glycerol kinase activity being ~80-fold higher than the hexokinase activity. | |
| dc.description.sponsorship | Metabolisme de l'acetyl-CoA et de l'acetate chez les trypanosomes: identification de nouvelles voies métaboliques spécifiques aux parasites | en_US |
| dc.description.sponsorship | Voies métaboliques glycosomales non glycolytiques: nouvelles fonctions pour le développement et la virulence des trypanosomes - ANR-15-CE15-0025 | en_US |
| dc.description.sponsorship | Alliance française contre les maladies parasitaires | en_US |
| dc.description.sponsorship | Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation - ANR-11-INBS-0010 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://hal.archives-ouvertes.fr/licences/copyright/ | |
| dc.subject.en | Trypanosoma brucei | |
| dc.subject.en | glycerol-to-glucose preference | |
| dc.subject.en | glycerol kinase | |
| dc.subject.en | hexokinase | |
| dc.subject.en | diauxie | |
| dc.subject.en | carbon catabolite repression | |
| dc.subject.en | glycosomes | |
| dc.subject.en | glycolysis/gluconeogenesis | |
| dc.title.en | Metabolic Contest, a New Way to Control Carbon Source Preference | |
| dc.type | Document de travail - Pré-publication | en_US |
| dc.identifier.doi | 10.1101/800839 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04833187 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.subtype | Prepublication/Preprint | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=ALLMANN,%20Stefan&WARGNIES,%20Marion&CAHOREAU,%20Edern&BIRAN,%20Marc&PLAZOLLES,%20Nicolas&rft.genre=preprint | |
