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Polymeric micelles and vesicles: biological behavior evaluation using radiolabeling techniques

dc.rights.licenseopen
hal.structure.identifierTechnol Educ Inst Athens
hal.structure.identifierNational Center for Scientific Research "Demokritos" [NCSR]
hal.structure.identifierUniv Hosp Larissa
dc.contributor.authorPSIMADAS, Dimitrios
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorDE OLIVEIRA, Hugo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorTHEVENOT, Julie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierNational Center for Scientific Research "Demokritos" [NCSR]
dc.contributor.authorBOUZIOTIS, Penelope
hal.structure.identifierNational Center for Scientific Research "Demokritos" [NCSR]
dc.contributor.authorVARVARIGOU, Alexandra D.
hal.structure.identifierUniv Hosp Larissa
dc.contributor.authorGEORGOULIAS, Panagiotis
hal.structure.identifierTechnol Educ Inst Athens
dc.contributor.authorLOUDOS, George
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2014
dc.identifier.issn1083-7450
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20331
dc.description.abstractEnThe application of combined diagnosis and therapy through nanotechnology applications is attracting increasing attention worldwide. Polymeric self-assembled nanoparticles (NPs) have been studied for this purpose. Micelles and vesicles with or without a magnetic core can efficiently carry diagnostic and/or therapeutic agents to a desired target. The biological behavior of these NPs has been evaluated in this study, after radiolabeling with Tc-99m. In vitro stability, in media that mimic the environment of the living body, was better for vesicles than for micelles at 1 h and decreased for both as time passed. After administration to healthy animals, all NPs presented major uptake at liver and spleen as expected. Biodistribution and imaging studies confirmed the higher uptake in these organs for the hybrid NPs and at higher extent for the ones with larger size, indicating that the magnetic load and size play an important role on in vivo distribution.
dc.language.isoen
dc.publisherTaylor & Francis
dc.subject.enBiodistribution
dc.subject.enimaging
dc.subject.ennanoparticles
dc.subject.entechnetium
dc.title.enPolymeric micelles and vesicles: biological behavior evaluation using radiolabeling techniques
dc.typeArticle de revue
dc.identifier.doi10.3109/10837450.2013.763264
dc.subject.halChimie/Polymères
bordeaux.journalPharmaceutical Development and Technology
bordeaux.page189-193
bordeaux.volume19
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue2
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00959611
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00959611v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pharmaceutical%20Development%20and%20Technology&rft.date=2014&rft.volume=19&rft.issue=2&rft.spage=189-193&rft.epage=189-193&rft.eissn=1083-7450&rft.issn=1083-7450&rft.au=PSIMADAS,%20Dimitrios&DE%20OLIVEIRA,%20Hugo&THEVENOT,%20Julie&LECOMMANDOUX,%20Sebastien&BOUZIOTIS,%20Penelope&rft.genre=article


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