Physiological and pathological roles of caveolins in the central nervous system
| dc.rights.license | open | en_US |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BADAUT, Jerome | |
| dc.contributor.author | BLOCHET, Camille | |
| dc.contributor.author | OBENAUS, André | |
| dc.contributor.author | HIRT, Lorenz | |
| dc.date.accessioned | 2024-11-13T12:45:20Z | |
| dc.date.available | 2024-11-13T12:45:20Z | |
| dc.date.issued | 2024-08-01 | |
| dc.identifier.issn | 0166-2236 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203230 | |
| dc.description.abstractEn | Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are diverse, and include mechano-protection, lipid homeostasis, metabolism, transport, and cell signaling. Caveolin-1 (Cav-1) and other caveolins were described in endothelial cells and later in other cell types of the central nervous system (CNS), including neurons, astrocytes, oligodendrocytes, microglia, and pericytes. This pancellular presence of caveolins demands a better understanding of their functional roles in each cell type. In this review we describe the various functions of Cav-1 in the cells of normal and pathological brains. Several emerging preclinical findings suggest that Cav-1 could represent a potential therapeutic target in brain disorders. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Blood–Brain Barrier | |
| dc.subject.en | Caveolae | |
| dc.subject.en | Lipid Rafts | |
| dc.subject.en | Neuroinflammation | |
| dc.subject.en | Neuronal Plasticity | |
| dc.subject.en | Neurovascular Unit | |
| dc.title.en | Physiological and pathological roles of caveolins in the central nervous system | |
| dc.title.alternative | Trends Neurosci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.tins.2024.06.003 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 38972795 | en_US |
| bordeaux.journal | Trends in Neurosciences | en_US |
| bordeaux.page | 651-664 | en_US |
| bordeaux.volume | 47 | en_US |
| bordeaux.hal.laboratories | Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04765883 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Trends%20in%20Neurosciences&rft.date=2024-08-01&rft.volume=47&rft.issue=8&rft.spage=651-664&rft.epage=651-664&rft.eissn=0166-2236&rft.issn=0166-2236&rft.au=BADAUT,%20Jerome&BLOCHET,%20Camille&OBENAUS,%20Andr%C3%A9&HIRT,%20Lorenz&rft.genre=article |
