Severe enterovirus infections in patients with immune-mediated inflammatory diseases receiving anti-CD20 monoclonal antibodies.
| dc.rights.license | open | en_US |
| dc.contributor.author | MARTIN DE FRÉMONT, Grégoire | |
| dc.contributor.author | CHABROLLES, Hélène | |
| dc.contributor.author | MIRAND, Audrey | |
| dc.contributor.author | L'HONNEUR, Anne Sophie | |
| dc.contributor.author | MÉLÉ, Nicolas | |
| dc.contributor.author | DUNOGUE, Bertrand | |
| dc.contributor.author | BOUTBOUL, David | |
| dc.contributor.author | FARHAT, Meryem | |
| dc.contributor.author | HACHULLA, Eric | |
| dc.contributor.author | LAZREK, Mouna | |
| dc.contributor.author | RIEU, Virginie | |
| dc.contributor.author | MATHIAN, Alexis | |
| dc.contributor.author | CHAUSSADE, Helene | |
| dc.contributor.author | RUET, Aurelie | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BURREL, Sonia | |
| dc.contributor.author | COURY-LUCAS, Fabienne | |
| dc.contributor.author | SCHUFFENECKER, Isabelle | |
| dc.contributor.author | LEMAIGNEN, Adrien | |
| dc.contributor.author | STEFIC, Karl | |
| dc.contributor.author | LE BESNERAIS, Maelle | |
| dc.contributor.author | CARRETTE, Marion | |
| dc.contributor.author | MOUTHON, Luc | |
| dc.contributor.author | AVETTAND-FENOEL, Veronique | |
| dc.contributor.author | TERRIER, Benjamin | |
| dc.contributor.author | HADJADJ, Jérome | |
| dc.date.accessioned | 2024-11-05T12:46:26Z | |
| dc.date.available | 2024-11-05T12:46:26Z | |
| dc.date.issued | 2024-05-20 | |
| dc.identifier.issn | 2056-5933 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203123 | |
| dc.description.abstractEn | Patients with X linked agammaglobulinemia are susceptible to enterovirus (EV) infections. Similarly, severe EV infections have been described in patients with impaired B-cell response following treatment with anti-CD20 monoclonal antibodies (mAbs), mostly in those treated for haematological malignancies. We aimed to describe severe EV infections in patients receiving anti-CD20 mAbs for immune-mediated inflammatory diseases (IMIDs). Patients were included following a screening of data collected through the routine surveillance of EV infections coordinated by the National Reference Center and a review of the literature. Additionally, neutralising antibodies were assessed in a patient with chronic EV-A71 meningoencephalitis. Nine original and 17 previously published cases were retrieved. Meningoencephalitis (n=21/26, 81%) associated with EV-positive cerebrospinal fluid (n=20/22, 91%) was the most common manifestation. The mortality rate was high (27%). EV was the only causal agents in all reported cases. Patients received multiple anti-CD20 mAbs infusions (median 8 (5-10)), resulting in complete B-cell depletion and moderate hypogammaglobulinemia (median 4.9 g/L (4.3-6.7)), and had limited concomitant immunosuppressive treatments. Finally, in a patient with EV-A71 meningoencephalitis, a lack of B-cell response to EV was shown. EV infection should be evoked in patients with IMIDs presenting with atypical organ involvement, especially meningoencephalitis. Anti-CD20 mAbs may lead to impaired B-cell response against EV, although an underlying primary immunodeficiency should systematically be discussed. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Humans | |
| dc.subject.en | Enterovirus Infections | |
| dc.subject.en | Male | |
| dc.subject.en | Female | |
| dc.subject.en | Antibodies | |
| dc.subject.en | Monoclonal | |
| dc.subject.en | Antigens | |
| dc.subject.en | CD20 | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Adult | |
| dc.subject.en | Meningoencephalitis | |
| dc.subject.en | Aged | |
| dc.subject.en | Rituximab | |
| dc.subject.en | B-Lymphocytes | |
| dc.subject.en | Agammaglobulinemia | |
| dc.subject.en | Inflammation | |
| dc.title.en | Severe enterovirus infections in patients with immune-mediated inflammatory diseases receiving anti-CD20 monoclonal antibodies. | |
| dc.title.alternative | RMD Open | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1136/rmdopen-2023-004036 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 38772678 | en_US |
| bordeaux.journal | RMD Open : Rheumatic & Musculoskeletal Diseases | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
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