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Urea levels and cardiovascular disease in patients with chronic kidney disease

dc.rights.licenseopenen_US
dc.contributor.authorLAVILLE, S.M.
dc.contributor.authorCOUTURIER, A.
dc.contributor.authorLAMBERT, O.
dc.contributor.authorMETZGER, M.
dc.contributor.authorMANSENCAL, N.
dc.contributor.authorJACQUELINET, C.
dc.contributor.authorLAVILLE, M.
dc.contributor.authorFRIMAT, L.
dc.contributor.authorFOUQUE, D.
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, C.
dc.contributor.authorROBINSON, B.M.
dc.contributor.authorSTENGEL, B.
dc.contributor.authorLIABEUF, S.
dc.contributor.authorMASSY, Z.A.
dc.contributor.authorAYAV, C.
dc.contributor.authorBRIANÇON, S.
dc.contributor.authorCANNET, D.
dc.contributor.authorHERPE, Y.-E.
dc.contributor.authorPASCAL, C.
dc.contributor.authorLANGE, C.
dc.contributor.authorLEGRAND, K.
dc.contributor.authorSPEYER, E.
dc.contributor.authorHANNEDOUCHE, T.
dc.contributor.authorMOULIN, B.
dc.contributor.authorMAILLIEZ, S.
dc.contributor.authorLEBRUN, G.
dc.contributor.authorMAGNANT, E.
dc.contributor.authorCHOUKROUN, G.
dc.contributor.authorDEROURE, B.
dc.contributor.authorLACRAZ, A.
dc.contributor.authorLAMBREY, G.
dc.contributor.authorPHILIPPE, J.
dc.contributor.authorBOURDENX
dc.contributor.authorESSIG, M.
dc.contributor.authorLOBBEDEZ, T.
dc.contributor.authorAZAR, R.
dc.contributor.authorSEKHRI, H.
dc.contributor.authorSMATI, M.
dc.contributor.authorJAMALI, M.
dc.contributor.authorKLEIN, A.
dc.contributor.authorDELAHOUSSE, M.
dc.contributor.authorMARTIN, S.
dc.contributor.authorLANDRU, I.
dc.contributor.authorTHERVET, E.
dc.contributor.authorLANG, P.
dc.contributor.authorBELENFANT, X.
dc.contributor.authorURENA, P.
dc.contributor.authorVELA, C.
dc.contributor.authorCHAUVEAU, D.
dc.contributor.authorPANESCU, V.
dc.contributor.authorNOEL, C.
dc.contributor.authorGLOWACKI, F.
dc.contributor.authorHOFFMANN, M.
dc.contributor.authorHOURMANT, M.
dc.contributor.authorBESNIER, D.
dc.contributor.authorTESTA, A.
dc.contributor.authorKUENTZ, F.
dc.contributor.authorZAOUI, P.
dc.contributor.authorCHAZOT, C.
dc.contributor.authorJUILLARD, L.
dc.contributor.authorBURTEY, S.
dc.contributor.authorKELLER, A.
dc.contributor.authorKAMAR, N.
dc.contributor.authorCOLLABORATORS, Ckd-Rein Study
dc.date.accessioned2024-10-25T09:09:38Z
dc.date.available2024-10-25T09:09:38Z
dc.date.issued2023-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202803
dc.description.abstractEnBackground: Elevated serum urea levels are common in moderate-to-advanced chronic kidney disease (CKD). Several studies have shown that urea is a direct and indirect uraemic toxin, especially with regard to cardiovascular disease. We sought to determine whether serum urea levels are associated with adverse cardiovascular events and death before renal replacement therapy (RRT) in patients with CKD. Methods: CKD-REIN is a prospective cohort of CKD nephrology outpatients not receiving maintenance dialysis. The 2507 patients included in the analysis were divided into three groups according to the baseline serum urea level (T1 <10.5, T2 10.5-15.1 and T3 ≥15.1 mmol/L). Cox proportional hazard models were used to estimate hazard ratios (HRs) for first atheromatous or non-atheromatous cardiovascular (CV) events and all-cause mortality before RRT. The models were adjusted for baseline comorbidities, laboratory data and medications. Findings: Of the 2507 included patients median [interquartile range (IQR)] age: 69 [61-77]; mean (standard deviation) estimated glomerular filtration rate (eGFR) 33.5 (11.6) mL/min/1.73 m², 54% had a history of cardiovascular disease. After multiple adjustments for CV risk factors (including eGFR), patients in T3 had a higher risk of atheromatous and non-atheromatous CV events than patient in T1 (n events = 451, HR [95% CI]: 1.93 [1.39; 2.69]). The adjusted HRs for death before RRT (n events = 407) were 1.31 [0.97; 1.76] and 1.73 [1.22; 2.45] for patients T2 and those in T3, respectively. Interpretation: Our data suggested that urea is a predictor of CV outcomes beyond CV risk factors including eGFR. © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA.
dc.language.isoENen_US
dc.title.enUrea levels and cardiovascular disease in patients with chronic kidney disease
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfac045en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.page184-192en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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